Codexis, Inc.

Martina Quintanar-Audelo

Derek J Smith

Steven James Collier

Jeffrey C Moore

Haibin Chen

Fabien Louis Cabirol

Yong Koy Bong

Yang Hong

Jovana Nazor

Tao Li

Ellen D Eberhard

Anupam Gohel Prafulchandra

Cuixia Wang

The present disclosure provides engineered transaminase polypeptides useful for the synthesis of chiral amine compounds under industrially relevant conditions. The disclosure also provides polynucleotides encoding the engineered transaminase polypeptides, host cells capable of expressing the engineered transaminases, and methods of using the engineered transaminases for the production of chiral amine compounds.

Engineered transaminase polypeptides for industrial biocatalysis

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Biocatalysts and methods for hydroxylation of chemical compounds

Engineered proline hydroxylase polypeptides and methods

Engineered proline hydroxylase polynucleotides and methods

Methods for hydroxylyation of chemical compounds

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts, methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts.

Engineered proline hydroxylase polypeptides

Growing community of inventors

Edinburgh, United Kingdom

Martina Quintanar-Audelo