Sanofi Pasteur Inc.

The Kingdom of the Netherlands, Represented by the Minister of Health, Welfare and Sport, on Behalf of the Minister, the National Institute of Public Health and the Environment

Martina Ochs-Onolemhemhen

Eliud Oloo

Raymond Oomen

Roger Brookes

Jeremy Yethon

Scott Gallichan

Garry Morefield

Michael Pichichero

Kevin Harper

Marie-Danielle Salha

Belma Ljutic

Claire-Anne Siegrest

Claire-Anne Siegrist

Fernando Ausar

This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.

Immunogenic compositions and related methods

This disclosure relates to immunogenic compositions comprising mutantpneumolysin (PLY) proteins. Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.

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Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.

This disclosure relates to modifiedpneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused byThe modified pneumolysm proteins comprise amino acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided.

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Lyons, France

Martina Ochs-Onolemhemhen