Dsm Fine Chemicals Austria Nfg Gmbh & Co. Kg

Dsm IP Assets B.v.

Esim Chemicals Gmbh

Dpx Holdings B.v.

Martina Kotthaus

Gerhard Steinbauer

Quirinus B Broxterman

Andreas Hendrikus Maria De Vries

Laurent Lefort

Peter Poechlauer

Johannes Gerardus De Vries

Anna Maria Cornelia Francisca Castelijns

Stefaan Marie Andre De Wildeman

Ulfried Felfer

Peter Pöchlauer

Rolf Marr

Thomas Zich

Andreas H M De Vries

Henricus Martinus Maria Gerardus Straatman

Rafael Wilhelmus Elisabeth Ghislain Reintjens

Martin Deak

Klaus Edegger

Jeroen Boogers

Martin Vorbach

Quirinus Bernardus Broxterman

The invention relates to a method for carrying out reactions with participation of carbocations, whereby the initial most strongly exothermic phase of the reaction is carried out at high temperature (60 to 120&#xb0; C.) and short residence time (1 to 30 seconds) in a microreactor and the subsequent less exothermic phases are carried out at optionally lower temperatures in two or more residence time units with longer residence times (1 to 30 seconds).

Stepwise execution of exothermic reactions with participation of carbocations

Multi-step process for the preparation of compounds via hazardous intermediates comprising the steps of a) preparing in a microreactor a hazardous intermediate and b) optionally performing one or more reaction steps on the hazardous intermediate in one or more additional microreactors and c) further converting the hazardous intermediate with a suitable reaction agent in a subsequent microreactor until a stable end product is formed.

Process for the production of compounds via hazardous intermediates in a series of microreactors

This invention relates to novel alpha-substituted &#x3b1;,&#x3b2;-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula (I) in which Rand Rmay be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and Rand Rmay be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and Rmay be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals. 

Alpha-substituted &#x3b1;,&#x3b2;-unsaturated E- or Z-aldehydes, use thereof, and processes for their preparation &#x3b1;,&#x3b2;

A process for transition metal-catalyzed, asymmetric hydrogenation of acrylic acid derivatives of the formula (I) in which R1 is H or an optionally substituted alkyl, aryl or heteroaryl radical, R2 is an optionally substituted alkyl, aryl or heteroaryl radical, and R3 is H or a C-C-alkyl radical, which comprises hydrogenating compounds of the formula (I), optionally in a solvent, in the presence of one or more hydrogen donors, using a catalyst system which comprises a transition metal from the group of ruthenium, rhodium and iridium and a combination of a chiral phosphorus ligand of the formula (II) in which Cn, together with the two oxygen atoms and the phosphorus atom, forms an optionally substituted ring having from 2 to 6 carbon atoms and R4 is an optionally substituted alkyl, aryl, alkoxy or aryloxy radical or NR5R6 where R5 and R6 may each independently be H or an optionally substituted alkyl, aryl, aralkyl or alkaryl radical, or, together with the nitrogen atom, may form a ring, and an achiral phosphine ligand of the formula (III) in which R is an optionally substituted alkyl or aryl radical, to the corresponding compounds of the formula (IV) in which R1, R2 and R3 are each as defined above, and also a novel catalyst system for asymmetric transition metal catalysis.

Process for transition metal-catalyzed asymmetric hydrogenation of acrylic acid derivatives, and a novel catalyst system for asymmetric transition metal catalysis

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Linz, Austria

Martina Kotthaus