Janssen Pharmaceuticals, Inc.

Lawrence Livermore National Security, LLC

Martina Felderman

Kurt Iver Kamrud

Nathaniel Stephen Wang

Nancy C Carrico

Matthew A Coleman

Nicholas O Fischer

Craig D Blanchette

Wei He

Amy Rasley

Angela Clare Evans

Kurt I Kamrud

Bolyn Hubby

Heather D Gouvis

Nathaniel S Wang

The present disclosure generally relates to viral-based expression systems suitable for the production of molecule of interests in recombinant host cells. The disclosure particularly relates to nucleic acid constructs, such as expression vectors, containing a modified arterivirus genome or replicon RNA in which at least some of its original viral sequence has been deleted. Also included in the disclosure are viral-based expression vectors including one or more expression cassettes encoding heterologous polypeptides. In some embodiments, the expression cassettes are configured and positioned at defined locations on the viral genome so as to enable expression of the heterologous polypeptides in a tunable manner.

Recombinant arterivirus replicon systems and uses thereof

Nanolipoprotein particles comprising at least a scaffold protein component and a membrane lipid component and related complexes, compositions, methods and systems are described, in which the membrane lipid component comprises at least one or more membrane forming lipids and one or more cationic lipids.

Nanolipoprotein particles and related compositions methods and systems for loading RNA

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La Jolla, CA, United States of America

Martina Felderman