Advec, Inc.

Technische Universitat Munchen

Martina Anton

Frank L Graham

Michael A Rudnicki

Silvia Bacchetti

Ping Wang

William J Muller

Horst Kessler

Norman Koglin

Oliver Demmer

Hans Jürgen Wester

Markus Schwaiger

Burkhardt Laufer

Provided herein are compounds or conjugates useful for diagnostic imaging and/or therapeutic purposes. Each compound or conjugate comprises a ligand for the chemokine receptor CXCR4 and a detectable label. The ligand has a binding affinity for the CXCR4 receptor, measured as ICin the presence ofI-CPCR4, of 250 nM or lower, and the ligand comprises a cyclic oligopeptide moiety having the motif B-Arg or B-(Me)Arg within the cyclic moiety, wherein B is a basic amino acid, a derivative thereof, or phenylalanine, provided that the motif is B-Arg when B is a N-methyl derivative of a basic amino acid.

Cancer imaging and treatment

This invention provides helper-dependent adenovirus cloning vectors and helper adenoviruses, and methods for making and Using such preparations, wherein the helper adenoviruses contain recombinase target sites that are useful in reducing the level of contamination of helper virus in helper-dependent adenovirus vector preparations.

Helper dependent adenovirus vectors based on integrase family site-specific recombinases

The invention claims a class of adenovirus vectors for delivering recombinases to a large number of cells of different origins, and methods for regulating the expression of a gene in transfected mammalian cells in culture and in cells of transgenic animals, comprising infecting said cells with an Ad vector encoding a recombinase whose target site is present at or adjacent to the gene, wherein the action of the recombinase regulates the expression of said gene.

Adenoviruses for control of gene expression

This invention provides a method for making adenovirus cloning vectors which contain a recombinase target site that is useful for the insertion of selected foreign proteins.

Adenoviral vector system comprising Cre-loxP recombination

Growing community of inventors

Vaterstetten, Germany

Martina Anton