Darwin Discovery Limited

Chiroscience, Ltd.

Martin Woods

Ulrich Conrad Dyer

Raymond McCague

Brian Michael Adger

Marianne Langston

Helen Frances Baker

John Francis Andrews

An optically-enrichedpiperidine-2-carboxanlidecompound, in which the piperidine is optionally N-alkylated, is racemized by heating the compound in an aqueous medium, provided that the medium includes an organic co-solvent if the compound is N-alkylated. This process is particularly valuable, in conjunction with a resolution process, for the manufacture of levobupivacaine.

Racemisation process for use in the manufacture of levobupivacaine and related piperidinecarboxanilide anaesthetic agents

A process for the preparation of optically-enriched pipecolic acid as a salt with an optically-active acid, comprises asymmetric transformation of pipecolic acid, as a racemic mixture of a mixture enriched in the opposite enantiomer from that desired, with the optically-active acid in a solvent comprising an acid that causes racemisation, in the absence of aldehyde.

Racemization of precursors to levobupivacaine and analogues thereof

Process for the resolution of etodolac using glucamine derivatives

Racemization and asymmetric transformation processes used in the

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Cambridge, United Kingdom

Martin Woods