Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts

Deutsches Krebsforschungszentrum Stiftung Des Off. Rechts

Martin Vingron

Ingrid Grummt

Antje Krause

The present invention relates to an RNA polymerase I transcription factor TIF-IA and proteins related thereto, whose concentration and/or activity are correlated with the cell proliferation rate, and to DNA sequences encoding these proteins. The present invention also concerns ligands binding to an RNA polymerase I transcription factor TIF-IA and proteins related thereto, respectively, antagonists as well as antisense RNAs and/or ribozymes, directed against the TIF-IA expression. These compounds are of use for the prevention or treatment of diseases associated with an increased or reduced cell proliferation.

RNA polymerase I transcription factor TIF-IA

In order to cluster sequences to biological groups, the conventional databank search programs are iteratively called in with a view to clustering various related sequences to one determined protein sequence. The inventive method enables full automatic distribution of a high number of protein sequences in groups. The major part of such groups are segregated, so that they represent a meaningful and valid grouping of data.

Growing community of inventors

Berlin, Germany

Martin Vingron