American Cyanamid Company

Martin Tobkes

Murray Dann

Lalitha Krishnan

Larry Dean Spicer

Irving Klothen

David R Williams

Simon Diaz

An improved process for producing the antibiotic compound clindamycin phosphate through the use of novel intermediate, 7(S)-chloro-7-deoxylincomycin-2-bis(2,2,2-trichloroethyl)phosphochloridate and similar compounds.

Clindamycin phosphate synthesis

This disclosure describes reversible complexes made from antibiotic trans-BM123.nu. and water soluble pamoate salts and a process for preparing same. These highly stable complexes are useful as animal feed supplements which significantly enhance the growth rate of animals and poultry.

Antibiotic BM123.nu. pamoate complexes

This disclosure describes reversible complexes of antibiotic trans-BM123.gamma. with a synthetic tanning agent and a process for preparing same. The complexes are useful as animal feed supplements which significantly enhance the growth rate of animals and poultry.

Antibiotic BM123 syntan complexes

This disclosure describes reversible complexes of antibiotic trans-BM123.gamma. with an alkali metal alkyl sulfate and a process for preparing same. The complexes are useful as animal feed supplements which significantly enhance the growth rate of animals and poultry.

Antibiotic BM123-alkyl sulfate complexes

This disclosure describes reversible complexes of antibiotic trans-BM123.gamma. with a dioctyl sulfosuccinate salt and a process for preparing same. The complexes are useful as animal feed supplements which significantly enhance the growth rate of animals and poultry.

Antibiotic BM123-dioctyl sulfosuccinate complexes

This disclosure describes a process for the recovery of 7-dimethylamino-6-demethyl-6-deoxytetracycline from an aqueous solution thereof by means of a calcium chloride complex of 7-dimethylamino-6-demethyl-6-deoxy-tetracycline hydrochloride.

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Spring Valley, NY, United States of America

Martin Tobkes