Biolex Therapeutics, Inc.

Isotis S.a.

Martin Stigter

Jeroen Mattijs Bezemer

Anne Chantal Bechet

Riemke Van Dijkhuizen-Radersma

Klaas De Groot

Pierre Jean F Layrolle

Yuelian Liu

Anne C Bechet

The invention discloses a pharmaceutical composition for the controlled release of relatively toxic active compounds, in particular for bioactive proteins from the class of interferons. The composition comprises a biodegradable block copolymer constructed from poly(ethylene glycol) terephthalate (PEGT) and poly(butylene terephthalate) (PBT). The composition is provided in the form of injectable microparticles, of an injectable liquid which may have self-gelling properties, or of a solid implant. The invention further provides a pharmaceutical kit comprising the composition, methods for preparing the composition, and the pharmaceutical uses relating thereto.

Controlled release compositions for interferon based PEGT/PBT block copolymers and method for preparation thereof

Controlled release compositions for interferon based on PEGT/PBT block copolymers and method for preparation thereof

Controlled release compositions for interferon based on PEGT/PBT block copolymers

The invention relates to the field of medical devices. More in particular, the invention relates to a method for coating by depositing inorganic ions and a bioactive agent to provide sterile medical devices, wherein said coating improves the biocompatibility and/or bioactivity of a medical device, such as an orthopedic or dental prosthesis. Furthermore, the invention relates to a medical device coated with a method according to the invention and to a reactor for use in a method according to the invention.

Method for applying a bioactive coating on a medical device

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Utrecht, Netherlands

Martin Stigter