Palo Alto Research Center Inc.

Verily Life Sciences LLC

Martin Sheridan

David Mathew Johnson

Scott Albert Uhland

Ramkumar Abhishek

Craig Eldershaw

Saroj Kumar Sahu

Jessica Louis Baker Rivest

Robert Thomas Krivacic

Vedasri Vedharathinam

Gabriel Iftime

Sean Roark Garner

Divyaraj Desai

Eric Peeters

Peter Kiesel

Noble Marshall Johnson

Joerg Martini

Philipp Helmut Schmaelzle

Peter Massaro

Michael I Recht

Ranjeet Balakrishna Rao

Richard J Steele

Jianyi Liu

Ashutosh Kole

Felicia Linn

Tim Curley

Timothy J Curley

Matthew Metlitz

Timothy D Stowe

Ashish V Pattekar

Benjamin David Krasnow

Christopher A Paulson

Gregory B Anderson

Bhaskar Saha

Tiantian Zha

Kimberly Kam

Angela DiCiccio

Victor Criswell

Annapurna Karicherla

Nigel Snoad

Jianer Bao

Kassidy MacPhail

Rajesh Kumar Padmarajan

A device can include a capsule containing an array of microneedles and a mechanical actuator. The device can be in an ingestible form for delivery to a duodenum or other target location within a subject and can release the mechanical actuator from constraint by the capsule in response to stimuli or conditions in or en route to the duodenum or other target location. The mechanical actuator upon release from constraint by the capsule can expand outwardly (e.g., responsive to a bias provided by a flexibly resilient material of the mechanical actuator) in a direction away from a central longitudinal axis of the mechanical actuator and drive the array of microneedles into penetrating engagement with a lining of the duodenum or other target location. The penetrating engagement can facilitate delivery of a biotherapeutic agent or other payload via the microneedles.

Pill with needle delivery system having outwardly expanding mechanical actuation

A system for targeted delivery of a medicament to the gastrointestinal tract (e.g., selectively to the duodenum) of a subject. The system includes a medicament, a mucoadhesive layer at least partially surrounding the medicament, and an enteric coating encasing the medicament and mucoadhesive layer. The enteric coating comprises a material degradable by a pH of the GI tract and a material digestible by a lipase. Also provided are method of making and using the system for targeted delivery of a medicament to the gastrointestinal tract. Also provided are a system for deploying a medicament-containing needle system using an expanding element. The system includes a medicament-containing needle system and an expanding element within a capsule. The capsule is initially coated with an enteric coating. As the enteric coating degrades the expanding element absorbs fluid that enters the capsule and expands to deploy the medicament-containing needle system from the capsule.

Enteric coating for targeting the duodenum

Systems and methods for continuous insects sensing are described. One example method includes receiving a flow at a singulator, the flow comprising one or more insects; singulating the insects into a single-file flow of insects; sensing, using a sensor, insects within the single-file flow of insects; and incrementing a counter based on each sensed insects in the single-file flow of insects. One example system includes a channel defining a flow path for a flow of insects; a singulator positioned within the flow path and arranged to receive the flow of insects within the channel, the singulator configured to singulate the insects into a single-file flow of insects; a sensor positioned and arranged to sense insects in the single-file flow; and a processor in communication with the sensor and a non-transitory computer-readable medium, the processor configured to execute processor-executable instructions stored in the non-transitory computer-readable medium to receive sensor signals from the sensor; and count a number of insects based on the received sensor signals.

Systems and methods for continuous insect sensing

Systems and methods for continuous insect pupae sensing are described. One example method includes receiving a flow at a singulator, the flow comprising one or more insect pupae; singulating the insect pupae into a single-file flow of insect pupae; sensing, using a sensor, insect pupae within the single-file flow of insect pupae; and incrementing a counter based on each sensed insect pupae in the single-file flow of insect pupae. One example system includes a channel defining a flow path for a flow of insect pupae; a singulator positioned within the flow path and arranged to receive the flow of insect pupae within the channel, the singulator configured to singulate the insect pupae into a single-file flow of insect pupae; a sensor positioned and arranged to sense insect pupae in the single-file flow; and a processor in communication with the sensor and a non-transitory computer-readable medium, the processor configured to execute processor-executable instructions stored in the non-transitory computer-readable medium to receive sensor signals from the sensor; and count a number of insect pupae based on the received sensor signals.

Systems and methods for continuous insect pupae sensing

Insect storage and dispensing system are described. An example system may include a dispensing container including at least one wall defining an interior volume for retaining a plurality of adult insects. The system may also include a piston that extends through a first opening of the dispensing container so as to expose a top face of the piston to the interior volume. Longitudinal movement of the piston toward a second opening of the dispensing container may dispense a portion of the plurality of insects from the dispensing container when the plurality of insects is retained in the dispensing container.

Insect storage and dispensing systems

Devices, systems, and methods for delivering fluid are provided. Devices include a housing configured for intravaginal deployment and retention, at least one reservoir configured to contain a fluid, and a fluid dispensing mechanism configured to dispense the fluid past the cervix and to the uterus of the subject. Methods include intravaginally deploying and retaining a device in the subject, and dispensing the fluid from the device such that the fluid is driven past the cervix to the uterus of the subject.

Implantable fluid delivery devices, systems, and methods

A method of joining fiberglass-reinforced composite pipes includes joining an inner tube of each pipe by fusion to form a fused bond, joining fiber reinforced polymer tubes of each pipe by depositing a silica glass particle epoxy directly on the fused bond and on bonded edges of the fiber reinforced polymer tubes as a composition to cover tube edges and the fused inner tube bond, and curing the composition.

Materials and method for joining fiber reinforced pipeline

An apparatus for tracking an amount of dispensed fluid, a system for fluid injection including the apparatus, and related methods of use are described. In an embodiment, the apparatus includes a dosage meter shaped to couple with a leadscrew and a cartridge containing a fluid for injection, and configured to track fluid injection. In an embodiment, the dosage meter includes an index wheel including a plurality of teeth, wherein the index wheel is shaped to position coaxially with a major axis of the leadscrew and to receive rotational motion from the leadscrew; and a cantilevered protrusion positioned to deflect due to contact with the plurality of teeth as the index wheel rotates coaxially with the leadscrew inducing a strain in the cantilevered protrusion, wherein the dosage meter outputs a signal indicative of the strain.

Dosage tracking apparatus, dosage tracking system, and related methods of use

An electrochemical metal alloy identification device employing electrolytes to measure and identify different potentials of alloys is presented. This includes physical structure, disposables, electrical systems, control circuitry, and algorithms to identify alloys.

Alloy identification device

Retention devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and at least one reservoir contained within the housing. The at least one reservoir may have an actuation end and a release end and contain at least one drug formulation. A plug may be contained within the at least one reservoir and be moveable from the actuation end toward the release end. The device may also include an actuation system operably connected to the actuation end of the at least one reservoir and configured to drive the at least one drug formulation from the reservoir. The device may also include at least one retention member affixed to the housing and movable between a non-stressed position, a deployment position, and a retention position for retaining the device in an intraluminal location in the subject.

Devices and methods for intraluminal retention and drug delivery

A variable lithographic cleaning apparatus, system and method works on the principle that dust and ink residue may be transferred from a lower surface energy reimageable conformable blanket surface to a higher surface energy surface low durometer cleaning member, such as the tacky roller, and then to an even higher surface energy cleaning member, such as the hard roller, which is hard and robust to scratching. The hard roller can then been scrubbed clean by an ink flushing device having a third cleaning member, such as a melamine sponge, wetted with a cleaning solution with the hard roller dried upon each rotation.

Cleaning system architecture with recirculating bath for variable data lithographic printing

A flowing electrolyte fuel cell system design (DHCFC-Flow) is provided. The use of a flowing oxygen-saturated electrolyte in a fuel cell offers a significant enhancement in the cell performance characteristics. The mass transfer and reaction kinetics of the superoxide/peroxide/oxide ion (mobile oxygen ion species) in the fuel cell are enhanced by recirculating an oxidizing gas-saturated electrolyte. Recirculating oxygen-saturated electrolyte through a liquid channel enhances the maximal current observed in a fuel cell. The use of a oxygen saturated electrolyte ensures that the reaction kinetics of the oxygen reduction reaction are fast and the use of convection ameliorates concentration gradients and the diffusion-limited maximum current density. The superoxide ion is generated in situ by the reduction of the oxygen dissolved in the gaseous electrolyte. Also, a dual porosity membrane allows the uniform flow of fuel (e.g., methane) on the fuel side, without allowing phase mixing. The capillary pressure for liquid intrusion into the gas phase and vice versa is quite large, estimated to be 1-10 psi. This makes it easier to control the fluctuations in gas/liquid velocity which might otherwise lead to phase mixing and the loss of fuel cell performance. In one variation, a dual-porosity membrane structure is incorporated in the system to allow uniform flow of fuel and prevent mixing of fuel with a liquid electrolyte.

Flowing electrolyte fuel cell with improved performance and stability

Embodiments are directed to an apparatus that includes a fluidic structure and optical components. The fluidic structure includes a transparent channel through which objects in an analyte fluid can travel along respective paths during operation of the apparatus. The optical components are configured to provide measurement light to the objects traveling through the transparent channel. The fluidic structure is configured to reversibly engage with a host structure. The host structure includes a source of the measurement light and electronics to receive and process output light emanating from the objects traveling in the channel. The fluidic structure makes an air-tight seal when engaged with the host structure.

Fluidic optical cartridge

Devices, systems, and methods for detecting estrus in subjects are provided. Devices include a housing configured for intravaginal/intrauterine deployment and retention and a sensor disposed in or on the housing, and are configured to use condition information sensed by the sensor to determine an estrus condition of the subject. Methods include deploying a device in the subject, sensing the condition information, and determining an estrus condition using the condition information. Systems include a device configured to communicate with a base station and/or with other implanted devices, which are located within a reception radius thereof, regarding the determined estrus condition.

Implantable estrus detection devices, systems, and methods

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Redwood City, CA, United States of America

Martin Sheridan