Thomas Helledays Stiftelse for Medicinsk Forskning

Biovitrum Ab

Martin Scobie

Thomas Helleday

Tobias Koolmeister

Sylvain Jacques

Evert Homan

Olov Wallner

Karl Sven Axel Vallin

Carl Martin Henriksson

Martin Haraldsson

Martin Henriksson

Lars Sandberg

Matthieu Frederik Desroses

Cynthia Paulin

Pål Stenmark

Karl Vallin

Roland Julius Yu Fiskesund

Marie-Caroline Jacques-Cordonnier

Christoffer Bengtsson

Sanjay Borhade

Bj&ouml;rn M Nilsson

A compound of formula I or a pharmaceutically acceptable salt thereof. The compound is useful in therapy, e.g. for the treatment of cancers, inflammation, autoimmune diseases and graft-versus host diseases (e.g. in transplantation patients). A pharmaceutical composition comprising the compound or its salt and a method for preparing the compound.

2,6-diamino-3,4-dihydropyrimidin-4-one derivatives and use thereof in therapy

A compound of formula (I) or a pharmaceutically acceptable salt thereof. The compound is useful in therapy, e.g. for the treatment of cancers, inflammation, autoimmune diseases and graft-versus host diseases (e.g. in transplantation patients). A pharmaceutical composition comprising the compound or its salt and a method for preparing the compound. 

A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions. 

MTH1 inhibitors for treatment of inflammatory and autoimmune conditions

A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer. 

MTH1 inhibitors for treatment of cancer

A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Pyrimidine-2,4-diamine derivatives for treatment of cancer

A compound of formula (I), or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1. 

Compounds and their use

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Uppsala, Sweden

Martin Scobie