Fresenius Kabi Deutschland Gmbh

Martin Schimmel

Klaus Sommermeyer

Frank Hacket

Wolfram Eichner

Michele Orlando

Elmar Kraus

Norbert Zander

Harald Conradt

Klaus Langer

Ronald Frank

Thomas Hey

Franziska Hauschild

Helmut Knoller

Andreas Mitsch

Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a covalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.

Conjugates of hydroxyalkyl starch and a protein

The invention relates to a method for the preparation of a hydroxyalkyl starch derivative which comprises reacting hydroxyalkyl starch (HAS) via the optionally oxidized reducing end of the HAS with the amino group M of a crosslinking compound which, apart from the amino group, comprises a specifically protected carbonyl group, namely an acetal group or a ketal group.

Hydroxyalkyl starch derivatives and process for their preparation

Conjugates of hydroxyalkyl starch and a protein are provided herein. The conjugates are formed by a convalent linkage between the hydroxyalkyl starch or a derivative of the hydroxyalkyl starch and the protein. Methods of producing the conjugates and the use of the conjugates also are provided herein.

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Oberursel, Germany

Martin Schimmel