Deutsches Krebsforschungszentrum

Ruprecht-karls-universitaet Heidelberg

Martin Schaefer

Uwe Haberkorn

Matthias Eder

Klaus Kopka

Ulrike Bauder-Wuest

Martina Benesova

Jens Cardinale

Ann-Christin Eder

Michael Eisenhut

Frederik Giesel

The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x-(B)-x-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; xis a spacer covalently connecting (A) and (B); xis a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein Rto R, R, a, b, Y and Xto Xhave the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition.

Double-labeled probe for molecular imaging and use thereof

The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers and imaging agents for various disease states of prostate cancer.

F-tagged inhibitors of prostate specific membrane antigen (PSMA) and their use as imaging agents for prostate cancer

The present invention relates to a compound of a pharmaceutically acceptable salt thereof of formula (I) wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; xis a spacer or a chemical single bond covalently connecting (A) to the rest of the molecule; xis a spacer or a chemical single bond covalently connecting (C) to the rest of the molecule. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition. 

The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: A compound or a pharmaceutically acceptable salt thereof of formula (I): (A)-x-(B)-x-(C), wherein (A) is at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; (C) a dye moiety; xis a spacer covalently connecting (A) and (B); xis a spacer or a chemical single bond connecting (B) and (C); wherein (C) has the formula wherein Rto R, R, a, b, Y and Xto Xhave the meaning as indicated in the claims and description. The invention further relates to compositions comprising said compounds as well as a method for detecting neoplastic cells in a sample in vitro with the aid of the compounds or composition. 

The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: (A) at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; and (C) at least one dye moiety; wherein said compound has a molecular weight of not more than 5 kDa. Further, the invention refers to a method for producing such compound and to the in vivo and in vitro uses thereof.

Growing community of inventors

Neckarsteinach, Germany

Martin Schaefer