Leland Stanford Junior University

Trigemina, Inc.

Healthpartners Research Foundation

Nocicepta LLC

The United States Government As Represented by the Department of Veterans Affairs

Healthpartners Research & Education

Martin S Angst

Daniel Jacobs

David C Yeomans

William Howard Frey, Ii

Lawrence Robert Toll

Anton Wyss-Coray

David K Stevenson

Saul A Villeda

Jian Luo

Joseph M Castellano

Mohammad S Ghaemi

Brice L Gauilliere

Xiaoyuan Han

Nima Aghaeepour

Jinte Middeldorp

Lawrence R Toll

Daniel I Jacobs

William H Frey

Brice L Gaudilliere

Multiparametric analysis is performed at the single cell level of biological samples obtained from an individual during pregnancy to obtain a determination of changes in immune cell subsets, which changes include, without limitation, altered activation states of proteins involved in signaling pathways. Changes occur in signaling pathways of these immune cells that are predictive of propensity to develop preeclampsia in the pregnancy.

Compositions and methods of prognosis and classification for preeclampsia

Methods and compositions are provided for treating a subject for aging-associated conditions, e.g., cognitive impairment conditions. Aspects of the methods include administering a young plasma-comprising blood product to an individual in need thereof, e.g., an individual suffering from or at risk of developing the aging-associated condition, e.g., aging-associated cognitive impairment. Also provided are compositions and kits thereof that find use in practicing methods of the invention.

Methods and compositions for treating aging-associated conditions

The invention provides for methods and compositions for treatment of pain via craniofacial mucosal administration of an analgesic compound (e.g. a non-opioid analgesic peptide, an NOP agonist or N/OFQ). Intranasal administration of certain analgesic peptides such as N/OFQ results in global analgesic effects.

Methods for treatment of pain

The present invention relates to methods for the treatment of headache and headache disorders. The methods comprise administration of an oxytocin peptide for the treatment of primary and secondary headaches or trigeminal neuralgia.

Methods for treatment of headaches by administration of oxytocin

The present invention relates to methods for the treatment or prevention of trigeminal nerve-associated pain, in particular chronic, acute and procedural-related pain. The methods comprise administration of analgesic agents to the trigeminal nerve system which results in analgesia to the facial or head region.

Therapy procedure for drug delivery for trigeminal pain

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Palo Alto, CA, United States of America

Martin S Angst