Dionex Softron Gmbh

Martin Rendl

Gervin Ruegenberg

Anne Morgenstern

The present invention relates to a method of operating a fluidic system, wherein the fluidic system comprises a fluidic resistive element, wherein the method comprises a defined volume flow step, wherein in the defined volume flow step, a defined volume of a fluid is forced to flow out of the fluidic resistive element, wherein the defined volume is the fluid flowing out of the fluidic resistive element in a first time interval defined by a time tand a time t, wherein the defined volume flow step comprises: at the time t, switching the system from a first operating state to a second operating state, to bring a pressure in the fluidic resistive element from a first pressure value to a second pressure value, the second pressure value exceeding the first pressure value, and at a time t, which is after the time tand not later than the time t, switching the system to a third operating state to bring the pressure in the fluidic resistive element to a third pressure value, the third pressure value being below the second pressure value. The present invention also relates to a corresponding system and a corresponding computer program product.

Operation of a fluidic system

A method for determining a state of a fluidic system can include measuring back pressures in the fluidic system at different times and determining a state of the fluidic system. The determination is based on at least the measured back pressures and on additional status information indicative of at least one status of the fluidic system at at least one of the different times.

State determination of a fluidic system

The present invention relates to a method for monitoring, wherein the sample injector comprises a sample storage portion and a volume displacement device. The method comprises obtaining a pressure characteristic indicative for a pressure of the sample storage portion. In addition, the method comprises obtaining a displacement characteristic indicative for a displacement volume of the volume displacement device, when the volume displacement device is fluidically connected to the sample storage portion. Based on the obtained pressure characteristic and the obtained measured displacement characteristic the method comprises determining at least one result. In addition, the present invention relates to a sample injector, sample injector system and a system configured to carry out the method.

Monitoring sample injectors

A method for measuring a flow of a fluid in a tube includes heating the fluid in the tube with a heating element. A first signal is measured with a first temperature sensing element at a first location. A second signal is measured with a second temperature sensing element at a second location. At least one temperature signal is calculated based on the first signal and the second signal. The at least one temperature signal includes a difference temperature signal and a sum temperature signal. The difference temperature signal is calculated based on a difference between the second signal and the first signal. The sum temperature signal is calculated based on a sum of the second signal and the first signal. The flow is derived based on the difference temperature signal, the sum temperature signal, or a combination thereof.

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Munich, Germany

Martin Rendl