Infinity Pharmaceuticals, Inc.

Infinity Discovery, Inc.

Q30 Sports Science, LLC

Johns Hopkins University

Martin R Tremblay

Alfredo C Castro

Andre Lescarbeau

Michael J Grogan

Somarajannair Janardanannair

Catherine Anne Evans

Tao Liu

Yi Liu

Pingda Ren

Liansheng Li

Katrina Chan

Daniel A Snyder

Karen J McGovern

Brian C Austad

Mark L Behnke

Stephane Peluso

Julian Adams

James R Porter

Marta Nevalainen

Michael Andrew Foley

Andre B Charette

Somarajan Nair Janardanan Nair

David Guenther Winkler

Vito J Palombella

Jeffery L Kutok

William Matsui

André B Charette

George Elvira

Stephan Georgiev

Karen J Mcgovern

Michael A Foley

A collar sized to be worn around the neck of a human subject has at least one member that defines an arc of less than 360° and greater than 180° having a diameter, a first compressor at a first end of the arc, a second compressor at a second end of the arc and a bend angle sensor. The collar is adapted to exert an inwardly-directed force on the first and second compressors when worn. The bend angle sensor is configured and positioned to detect a bend angle of the collar, wherein the bend angle correlates to the inwardly-directed force on the first and second compressors when worn.

Traumatic brain injury protection devices

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Heterocyclic compounds and uses thereof

The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula: 

Methods of use of cyclopamine analogs

The invention provides derivatives of cyclopamine having the following formula: 

Cyclopamine analogs

Trisubstituted bicyclic heterocyclic compounds (e.g., pyridopyrimidinones) and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Provided herein are compounds of Formula (I&#x2033;) or (A&#x2033;), pharmaceutical compositions comprising the compounds, and methods of use thereof. The compounds provided herein modulate kinase activity, including PI3 kinase activity, and are useful for treating diseases and conditions associated with kinase activity, including PI3 kinase activity. 

Trisubstituted bicyclic heterocyclic compounds (e.g., chromenones and quinolines) and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Growing community of inventors

Melrose, MA, United States of America

Martin R Tremblay