Cidara Therapeutics, Inc.

Napp Pharmaceutical Group Limited

Other

Martin Patrick Hughes

Balasingam Radhakrishnan

David Hughes

Robert Michael Hughes

Yannick Borguet

Navdeep Balkrishna Malkar

Anuradha Vaidya

Kenneth Bartizal

Paul Daruwala

Steven McIntyre

Yanfeng Zhang

Lawrence R Folsom

Clive Tucker

Steven L Adams

Robert E Thompson

Robert J Kogut

Jianwei Shen

Tracy Walker

Alan Thompson

Cen Chen

George R Wilson, Jr

The present invention relates to echinocandin cyclopeptides and to methods for preparing echinocandin cyclopeptides.

Synthesis of echinocandin antifungal agent

The present invention relates to crystalline polymorphs of an echinocandin antifungal agent and novel methods for their preparation.

Polymorph of echinocandin antifungal agent

The disclosure features non-irritating pharmaceutical compositions containing CD101 in pharmaceutical acceptable salt (e.g., CD101 acetate) or neutral form. The pharmaceutical compositions can be intravenously administered to a subject to treat fungal infections (e.g., candidiasis) in the subject.

Compositions and methods for the treatment of fungal infections

A gun system has a two piece cannon assembly that is separated between a removable chamber instead of a traditional breech, and a projectile forcing cone. The chamber has a plug at one end that can accommodate any type of ignition system, and the other end is open and is attached to the barrel with a connection fitting. High pressure gases created by combustion of the propellant are sealed with a high-pressure gas compression seal at the interface between the chamber and the barrel. The connection fitting provides an attachment for a rear cannon bearing slide, which rides on rails attached to the main support structure, and also reacts any torque induced into the barrel from the actuation of the chamber/barrel locking collar. A turntable upon which are mounted two chamber elevating/support mechanisms and two projectile loader/rammer mechanisms is positioned around one of the main support structure legs.

Compact artillery

Growing community of inventors

Spokane, WA, United States of America

Martin Patrick Hughes