Smithkline Beecham Corporation

Astrazeneca Ab

Martin Pass

Hazel Joan Dyke

David E Bays

Colin David Eldred

Henry Anderson Kelly

David Glynn Smith

Richard Peter Charles Cousins

Andrew Michael Kenneth Pennell

Brian David Judkins

Alan Naylor

Malcolm Clive Carter

Neil Anthony Pegg

Jeremy John Payne

The invention concerns pyrimidine derivatives of Formula (I) wherein each of Q, G, G, q, R, r, R, Xand Qhave any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the production of an anti-proliferative effect in a warm-blooded animal such as man. 

2,4,6-trisubstituted pyrimidines as phosphotidylinositol (PI) 3-kinase inhibitors and their use in the treatment of cancer

A compound of formula (I): and pharmaceutically acceptable derivatives thereof, wherein Ris H or Calkyl; Ris wherein defines the point of attachment of the ring; and Ris Calkyl or NH. Compounds of formula (I) are potent and selective inhibitors of COX-2 and are of use in the treatment of pain, fever, inflammation of a variety of conditions and diseases.

Substituted pyrimidines as selective cyclooxygenase-2 inhibitors

A method of treating a patient suffering from or susceptible to ischemic heart disease, peripheral vascular disease or stroke or which subject is suffering pain, a CNS disorder or sleep apnea which comprises administering a therapeutically effective amount of an adenosine derivative which is an agonist at the adenosine A1 receptor and which exhibits little or no agonist activity of the A3 receptor. The adenosine derivative has a general formula (I) as follows:

Adenosine derivatives and methods of administration

Benzamide derivatives as thrombin inhibitors

A compound of formula (I) which is an agonist at the adenosine Al receptor, wherein Y, Z, and W represent heteroatoms, and salts and solvates thereof, in particular, physiologically acceptable solvates and salts thereof for use in therapy.

Adenosine derivatives

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Macclesfield, United Kingdom

Martin Pass