Vbi Technologies, LLC

Vcell Therapeutics, Inc.

Other

Children's Medical Center Corporation

Martin P Vacanti

Joseph P Vacanti

Yoshiki Sasai

Charles Alfred Vacanti

Masayuki Yamato

Koji Kojima

Haruko Obokata

Teruhiko Wakayama

The technology described herein relates to methods, assays, and compositions relating to causing a cell to assume a more pluripotent state, e.g. without introducing foreign genetic material.

Generating pluripotent cells de novo

Subpopulations of spore-like cells expressing specific cell surface and gene expression markers are provided. In one embodiment, the cells express at least one cell surface or gene expression marker selected from the group consisting of Oct4, nanog, Zfp296, cripto, Gdf3, UtF1, Ecat1, Esg1, Sox2, Pax6, nestin, SCA-1, CD29, CD34, CD90, B1 integrin, cKit, SP-C, CC10, SF1, DAX1, and SCG10. Also provided are methods for purifying a subpopulation of spore-like cells of interest from a population of spore-like cells, and methods for inducing differentiation of the isolated spore-like cells into cells of endodermal, mesodermal or ectodermal origin. The spore-like cells can be used to generate cells originating from all three germ layers and can be used to treat a patient who has a deficiency of functional cells in any of a wide variety of tissues, including the retina, intestine, bladder, kidney, liver, lung, nervous system, or endocrine system.

Subpopulations of spore-like cells and uses thereof

Highly undifferentiated spore-like cells can be isolated from many different tissues and bodily fluids and used to treat a wide variety of disorders.

Spore-like cells and uses thereof

Compositions and methods for growing new skin, which can be used to repair or replace skin that has been damaged or removed by a variety of insults.

Compositions and methods for generating skin

The invention features a method for generating new tissue by obtaining a liquid hydrogel-cell composition including a hydrogel and tissue precursor cells; delivering the liquid hydrogel-cell composition into a permeable, biocompatible support structure; and allowing the liquid hydrogel-cell composition to solidify within the support structure and the tissue precursor cells to grow and generate new tissue. The invention also features a tissue forming structure including a permeable, biocompatible support structure having a predetermined shape that corresponds to the shape of desired tissue; and a hydrogel-cell composition at least partially filling the support structure, wherein the hydrogel-cell composition includes a hydrogel and tissue precursor cells. The new tissue forming structure can be used in new methods to generate various tissues (e.g., to treat defective tissue) including new bone, cartilage, and nervous tissue such as spinal cord tissue. The invention also new isolated nervous system stem cells.

Population of undifferentiated neural, endocrine or neuroendocrine cells in a hydrogel support

The invention provides methods of generating a natural, living biological matrix that can serve as, or form a part of, a natural biological scaffold. The matrix is generated by incubating together biological cells and cellular debris. Any naturally occurring cell can be a biological cell included in the matrix. The invention also provides methods of treating a patient by implanting the matrix or scaffolding into a tissue of the patient, thereby augmenting the existing tissue.

Biological scaffolding material

Highly undifferentiated spore-like cells can be isolated from many different tissues and bodily fluids after those tissues and fluids have been exposed to extreme conditions. The spore-like cells can be used to treat a wide variety of disorders.

Growing community of inventors

Manhattan, KS, United States of America

Martin P Vacanti