Reilly Industries, Inc.

Vertellus Holdings LLC

Other

Martin P Grendze

Ramiah Murugan

Eric F V Scriven

Frank Verhoff

John T Wyeth

Donald W McQuigg

Edward P Frappier

Francis H Verhoff

Charles R Hopper

L Mark Huckstep

Angela R Sherman

Ernest Crowe

Phillip B Lawin

Katherine M Weisheit

James E Davis

Kuen-Wai Chiu

Susan L Vorhies

Process for converting a carboxamide to a thiocarboxamide includes reacting (a) a substrate that comprises a heteroatom-containing moiety and a carboxamide moiety with (b) a dialkyl dithiophosphate and/or a salt thereof. The heteroatom-containing moiety includes a heteroatom selected from the group consisting of N, O, and S. Processes for preparing piperidine-4-thiocarboxamide are described.

Processes for converting carboxamides to thiocarboxamides

Processes for the preparation of 2-chloro-5-methylpyridine are described.

Process for making 2-chloro-5-methylpyridine

Methods are provided for improving production of 3,5-diethyl-1,2-dihydro-1-phenyl-2-propylpyridine (DHP). In one illustrative embodiment, the methods involve controlling the rate of reaction and temperature of the reaction during formation of DHP. In another illustrative embodiment, the methods involve neutralizing the acid catalyst subsequent to DHP formation.

Process for the preparation of 3,5-diethyl-1,2-dihydro-1-phenyl-2-propylpyridine

Described are non-swelling, crosslinked, bead forms of ampholytic base polymers that can be utilized in the chromatographic-type separation of acids from other compounds. Preferred polymers are prepared by modifying a poly-2 or poly-4-vinylpyridine resin crosslinked with divinylbenzene.

Crosslinked, non-swellable ampholytic base resins

Described are processes for producing citrate esters in, an economic fashion. Esters are prepared by esterification of a citric acid-containing fermentation broth having been treated to remove cations and optionally other impurities, but containing sugar(s). Esters are also prepared by reacting an impure aqueous citric acid source with an alcohol to provide a heterogeneous aqueous/organic reacted mixture, wherein the organic phase contains the ester and the aqueous phase retains water-soluble impurities. A liquid phase separation is then used to separate the organic and aqueous phases, conveniently separating the impurities from the product and avoiding the energy-intensive distillation of water from the reaction medium.

Processes for producing citrate esters

Described are preferred processes separating desired chemical products from impurities in solution utilizing thermally-managed chromatography over solid adsorbents. The preferred processes involve chromatographic principles which are assisted by varying the temperature of operation in separation and elution phases. Also described are processes for treating aqueous acids to dewater and recover the acids in an organic solvent such as an alcohol.

Thermally-managed separation and dewatering processes for recovering acid products

Described are processes for the large, commercial scale production of USP grade nicotinamide, wherein the USP grade product is isolated using novel strategies which minimize product waste, and avoid the need for crystallizations and/or ameliorate complications arising in crystallization strategies. Preferred processes involve the processing of nicotinamide reaction crudes over both cation exchange and weak base resins and the subsequent recovery of USP grade nicotinamide by simple evaporation.

Processes for producing highly pure nicotinamide

Thermally-managed separation and dewatering processes for recovering

Desorption process and apparatus

Chichibabin aminations of pyridine bases

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Indianapolis, IN, United States of America

Martin P Grendze