Sanofi-a Ventis Deutschland Gmbh

Aventis Pharma Deutschland, Gmbh

Hoechst Marion Roussel Deutschland Gmbh

Martin Opper

Klaus Bosslet

Joerg Czech

The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in. In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.

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The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.

Cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion proteins in E. coli

The invention relates to the cytoplasmic expression of antibodies, antibody fragments and antibody fragment fusion molecules in E. coli. In particular, antibody fragment fusion molecules having an antibody moiety which is directed against tumors and an enzyme moiety which cleaves a nontoxic prodrug to give the toxic drug can be advantageously prepared in this way while retaining their respective functional properties.

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Marburg, Germany

Martin Opper