Degussa Aktiengesellschaft

Skw Trostberg Aktiengesellschaft

Skw Trotestberg Ak

Evonik Degussa Gmbh

Martin Ober

Jürgen Heidlas

Johann Wiesm&uuml;ller

J&uuml;rgen Heidlas

Karsten Korth

Jan Cully

Oliver Klockmann

Jurgen Heidlas

Reimund Pieter

Franz Michlbauer

Kurt Stork

Rudolf Zobel

J&uuml;rgen Graefe

Karl-Heinz Zirzow

Kurt Eichenauer

Johann Wiesmüller

Johann Obersteiner

Zhengfeng Zhang

The invention relates to a method for impregnating a support matrix with solid and/or liquid compounds using a compressed gas or a compressed mixture of gases at densities ranging from 0.15 to 1.3 kg/l and at least two unsymmetrical pressure changes (pulsations). The method is further characterized in that both a multitude of impregnating substances such as biologically active compounds, technical materials or metal-organic compounds, as well as support matrices of biological origin and organic or inorganic substances can be used that have large inner surfaces and/or inner surfaces that are difficult to access.

Method of impregnating a carrier a matrix with solid and/or liquid compounds using compressed gases, and materials thus impregnated

Silane-modified oxidic or siliceous filler with a bead fraction below 75 &#x3bc;m of less than 15 wt. % and a median particle size distribution between of 150 to 500 &#x3bc;m, which is produced by the reaction of at least one microbeaded or microgranular, oxidic or siliceous filler in a compressed gas with at least one silane. The silane-modified oxidic or siliceous fillers are used in rubber compounds.

Silane-modified oxidic or siliceous filler, process for its production and its use

For the preparation of pulverulent particle-reduced formulations with the aid of compressed gases, the solid compound to be formulated, a poorly soluble and usually bioactive active compound, is homogeneously ground together with 10-99% by weight (based on the formulation) of a carrier material which is essentially soluble in the compressed gas mixture, in the presence of compressed gas or mixtures thereof in a stirred autoclave having a mechanical grinding device at process temperatures between 10 and 200&deg; C. and at process pressures between 5 and 500 bar, and in a second process stage the compressed gas mixture, usually dimethyl ether, pure propane and/or carbon dioxide, is expanded by lowering the pressure and separated off from the homogenate, which can also be present as a melt. Finally, the pulverulent particle-reduced formulation is recovered from the homogenate obtained, with which significant improvements in the solubility properties and in particular in the bioavailability of originally poorly soluble and nonsoluble compounds are to be achieved.

Method for producing powdery particle-reduced formulations with the aid of compressed gases

The invention relates to oil-free glycerophospholipid formulations which contain a homogeneous mixture of glycerophospholipids and an anhydrous, liquid polyol compound such as glycerol in a molar ratio of 1:0.1 to 1. These formulations are produced, eg, by extracting a starting material consisting of an oil-containing glycerophospholipid (mixture) and the polyol component with a compressed hydrocarbon (mixture) in a rectifying column. The oil-free formulation can be obtained from the melt at the bottom of the column in the form of free-flowing powder, which is ideally suited for stabilising oil-in-water emulsions.

Oil-free glycerophospholipid formulations and method for the production thereof

Disclosed is a process for the fractionation of wool wax acid mixtures by dissolving the starting material in a polar organic solvent (mixture). The dissolved wool wax acid mixture is treated at a temperature between -5 and 30.degree. C. and at a pressure between 10 and 70 bar with gaseous carbon dioxide and the hydroxy-fatty acids that accumulate as a solid are separated from the solution.

Process for the fractionation of wool wax acid mixtures

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Altenmarkt, Germany

Martin Ober