Loyola University of Chicago

Behringwerke Aktiengesellschaft

Other

Behring Diagnostics Gmbh

Martin Muller

Lutz Gissmann

Jian Zhou

Jeanette Painstil

Conrad Bleul

Dusan Bartsch

Vaccine formulations comprising viral capsomeres are disclosed along with methods for their production. Therapeutic and prophylactic methods of use for the vaccine formulations are also disclosed.

Papilloma virus capsomere vaccine formulations and methods of use

The invention relates to the recombinant production of proteins as well as VLPs which are suitable as a vaccine for therapeutic and prophylactic vaccination. The invention also relates to processes for the production and purification of recombinant papilloma virus proteins and fusion proteins.

Papilloma virus-like particles, fusion proteins as well as processes for their production

Papillomavirus-like particles (VLPs) comprising truncated L1 proteins are provided wherein the L1 proteins have one or more carboxy terminal amino acid residues deleted.

Carboxyl terminal of papillomavirus L1 region is not required for formation of virus-like particles

Carboxyl terminal of papilloma virus L1 region is not required for

The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18. In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or in part with the sequences of the seroreactive epitopes, and to vaccines which contain such peptides.

Seroreactive epitopes on proteins of human papilloma-virus (HPV) 18

The present invention relates to the use of human paillomavirus 16 (HPV-16) E7-gene derived peptides for the diagnostic identification of HPV-16-associated invasive cervical cancer.

Use of HVP-16 E6 and E7-gene derived peptides to diagnose

The invention describes two immunogenic regions of the E7 protein of human papillomavirus type 16 (HPV 16), one immunoreactive region being located downstream from nucleotide 595 and the other being located downstream from nucleotide 667 of the HPV 16 genome.

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Neckargemund, Germany

Martin Muller