Ipsen Pharma S.a.s.

Societe De Conseils De Recherches Et D'applications Scientifiques

Martin Montes

Roland Cherif-Cheikh

Chantal Roume

Thomas Ciaran Loughman

Didier Bourissou

Blanca Martin-Vaca

Joël Richard

Magalie Graullier

Fabien Jeannerot

Frédéric Ben

Frédéric Lacombe

Fédéric Lacombe

Maria-Luisa Torres Salgado

Perrine Cambriel

Mercé Cardus Malaspina

Isabel Diaz Del Consuelo

Marie Delporte

Anne Brochard

Roland Cherif-cheikh

Mercè Cardus Malaspina

A process for the preparation of injectable pharmaceutical compositions for the sustained release of somatostatin analogs and compositions prepared according to the process. The process may comprise lyophilizing a mixture of lanreotide acetate and acetic acid to form a lyophilizate and hydrating the lyophilizate, wherein the lyophilization is performed only once.

Process for the preparation of pharmaceutical compositions for the sustained release of somatostatin analogs

The invention relates to a process for the preparation of injectable pharmaceutical compositions for the sustained release of somatostatin analogues and to pharmaceutical compositions prepared according to the process. In a preferred aspect the process comprises the steps of combining lanreotide acetate and acetic acid, lyophilizing the resulting mixture only once, and hydrating the lyophilizate. Acetic acid may be added to a desired pH during the final step of the process.

The present invention relates to pharmaceutical compositions for the controlled and sustained release of active substance comprising a biodegradable polymer or copolymer. Furthermore, the invention relates to pharmaceutical compositions for the controlled and sustained release of at least one active substance such as peptides or hormones and analogs thereof and the manufacturing process of such pharmaceutical compositions.

Sustained release formulations comprising GNRH analogues

The invention relates to a novel method for the synthesis of 2,5-dioxane-1,4-diones having formula (I), comprising the oxidation of the ketone function of a cyclic compound having formula (II), wherein R, R, Rand Rindependently represent the hydrogen atom, halo, (C-C) alkenyl, (C-C)cycloalkyl, cyclohexenyl and a radical having formula &#x2014;(CH)&#x2014;V&#x2014;W. 

Method for synthesis of 2,5-dioxane-1,4-diones

Growing community of inventors

Sant Quirze de Valles, Spain

Martin Montes