Novartis Ag

Signal Pharmaceuticals, Inc.

Novartis Pharma Gmbh

Martin Missbach

Claudia Betschart

Junichi Sakaki

Rene Lattmann

Naoki Teno

Eva Altmann

Genji Iwasaki

Kenji Hayakawa

Osamu Irie

Shripad S Bhagwat

Jeffrey A McKie

Johanne Renaud

John Henry Van Duzer

Ruben Alberto Tommasi

Leslie Wighton McQuire

Paul David Greenspan

Scott Douglas Cowen

Keigo Gohda

Miyuki Horiuchi

Michihiro Takai

The invention provides compounds of formula I or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors.

Heteroaryl nitrile derivatives

The invention provides compounds of Formula (I) or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors. 

Hetereoaryl nitrile derivatives

The invention provides compounds of Formula I or a pharmaceutically acceptable salt or ester thereof wherein the symbols have meaning as defined, which are inhibitors of cathepsin K and find use pharmaceutically for treatment of diseases and medical conditions in which cathepsin K is implicated, e.g. various disorders including inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors. 

Pyrrolo pyrimidines as agents for the inhibition of cystein proteases

Benzopyranone Compounds having the following structure: 

Benzopyranone compounds, compositions thereof, and methods of treatment therewith

Dipeptide nitrile cathepsin K inhibitors

Benzopyrazone compounds, compositions thereof, and methods of treatment therewith

Dipeptide nitriles

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Gipf-Oberfrick, Switzerland

Martin Missbach