University of California

Neuralstem, Inc.

Martin Marsala

Karl K Johe

Thomas Hazel

Osamu Kakinohana

Atsushi Miyanohara

Thomas G Hazel

Takahiro Tadokoro

Vassilis Koliatsos

Osamu Kakinohama

Paul J Reier

Margaret J Velardo

Jun Yan

The present invention provides a therapy for treating neuropathic pain by subpial administration of small quantities of a composition for spinal segment-specific upregulation of GAD65 (glutamatedecarboxylase) gene and VGAT (vesicular GABA transporter) gene, which is effective for induction of nociceptive effects by potentiating release of vesicular GABA from infected dorsal horn neurons into the synaptic cleft.

Method and composition for treating neuropathic pain

The present invention provides a therapy for treating loss of GABA-mediated pre-synaptic inhibition after spinal injury. The therapeutic regimen includes spinal segment-specific upregulation of GAD65 (glutamate decarboxylase) and VGAT (vesicular GABA transporter) to modulate chronic spasticity in patients after spinal traumatic or ischemic injury.

Method and composition for treating neuronal hyper-excitabtiity

Surgical needle

Delivery devices, systems, and methods related thereto may be used on patients for spinal delivery of cells, drugs, or vectors. The patient population may include patients with spinal traumatic injury, amyotrophic lateral sclerosis, multiple sclerosis, spinal ischemia, and other spinal neurodegenerative disorder that will require spinal cell, vector, or drug delivery.

Subpial delivery system and methods of use

Delivery devices, systems, and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. Thus, the system enables subpial delivery, which leads to a near complete spinal parenchymal AAV9-mediated gene expression or distribution in both white and grey matter.

Spinal subpial gene delivery system

The invention relates generally to methods of treating spasticity, rigidity, or muscular hyperactivity conditions by introducing a portion of an expanded population of neural stem cells into an area of a recipient spinal cord.

Methods of treating neurodegenerative conditions

Methods of treating ischemic spasticity

Delivery devices and methods related thereto may be used in humans for spinal delivery of cells, drugs or vectors. The patient population may include patients with spinal traumatic injury, amyotrophic lateral sclerosis, multiple sclerosis, spinal ischemia and any other spinal neurodegenerative disorders which will require spinal cell, vector or drug delivery. Unlike conventional methods which require multiple injection sites to make multiple, localized substrate deliveries, the delivery devices and methods of the present invention may allow for multiple substrate delivery locations with homogeneous substrate delivery with a single injection site.

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San Diego, CA, United States of America

Martin Marsala