Dermagen Ab

Pergamum Ab

Martin Malmsten

Artur Schmidtchen

Björn Walse

An antimicrobial peptide with heparin binding activity is described. It can be derived from endogenous mammalian proteins being substantially free from antimicrobial activity selected from the group consisting of laminin isoforms, complement factor C3, histidin rich glycoprotein and kininogen and having from 10 to 36 amino acids residues, wherein the antimicrobial peptide consists of at least four amino acid residues selected from the group consisting of K,R, and H. Also described are pharmaceutical compositions comprising said antimicrobial peptide and use of the antimicrobial peptide and/or antimicrobial/pharmaceutical composition.

Antimicrobial peptides with heparin binding activity

The invention relates to an antimicrobial peptide comprising a first set of amino acid residues having a length of from about 2 to about 36 amino acid residues or analogues thereof linked to the amino or carboxyterminal end a second set comprising from 3 to 8 hydrophobic amino acid residue or analogue thereof, wherein said peptide has an antimicrobial activity.

Antimicrobial peptides

The invention relates to a molecule comprising at least the amino acid sequence XXXXXXW XXXwherein Xis any amino acid residue, Xis I, L or V, Xis not C, Xis A, E, Q, R or Y, Xis not R, Xis I or L, Xis not H and wherein said molecule have a length of from about 10 to about 100 amino acid residues or an analogue thereof. The invention also relates to compositions comprising said molecule and use of the molecule and/or composition of the invention to combat microorganisms, such as bacteria, viruses, fungi, including yeast, and parasites.

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Täby, Sweden

Martin Malmsten