Smithkline Beecham Corporation

Other

Smithkline Beckman Corporation

The United States of America As Represented by the Department of Health

Affinium Pharmaceuticals, Inc.

Martin M Rosenberg

Judith M Ward

John Edward Hodgson

Michael Terence Black

Michael Arthur Lonetto

Richard Oakley Nicholas

Julie M Pratt

Raymond Winfield Reichard

David Justin Charles Knowles

Martin Karl Russel Burnham

Patrick Vernon Warren

Martin Karl Burnham

Richard Lloyd Warren

David Justin Knowles

Christopher Michael Traini

Leslie Marie Palmer

Jason Craig Fedon

Min Wang

Deborah Dee Jaworski

Andrew P Fosberry

Elizabeth J Lawlor

John E Hodgson

Martin Karl Russell Burnham

Ariane Adrienne Van Der Straten-Ponthoz

Hanne Ranch Johansen

Elizabeth Jane Lawlor

Lisa Kathleen Shilling

Christine Marie Debouck

Jeffrey L Mooney

Robert B Kirkpatrick

Yi Yi Zhong

James E Strickler

James A Fornwald

Dean P Taylor

Thomas R Berka

Joselina G Gorniak

Magdalena Zalacain

Sanjoy Biswas

Damien McDevitt

Tong Li

Martin K R Burnham

Robert H Reid

Phillip N Zarfos

Yi Y Zhong

Jamie M Pratt

Raymond Winfield Riechard

Simon J Foster

Julie Adamou

Richard Oakly Nicholas

Jeffrey I Auerbach

Jeffry J Leary

Craig W Adams

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

Nucleic acid sequences for HC gp-39L are provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.

Human cartilage glycoprotein

Nucleic acid sequences for HC gp-39L is provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.

The invention provides spo0J1 polypeptides and polynucleotides encoding spo0J1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo0J1 polypeptides to screen for antibacterial compounds.

Polynucleotide encoding spo0J1 of Staphylococcus aureus

The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.

The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.

Member of ATP dependent protease family, clpL

The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.

ribB

The invention provides rnc polypeptides and DNA (RNA) encoding rnc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing rnc polypeptides to screen for antibacterial compounds.

Ribonuclease III from Streptococcus pneumoniae

The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.

Prokaryotic polynucleotides polypeptides and their uses

The invention provides mecB polypeptides and polynucleotides encoding mecB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mecB polypeptides to screen for antibacterial compounds.

MecB

The invention provides RncS polypeptides and DNA (RNA) encoding RncS polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing RncS polypeptides to screen for antibacterial compounds.

Polynucleotides encoding a ribonuclease s

The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai polypeptides to screen for antibacterial compounds.

The invention provides phoH homolog polypeptides and DNA (RNA) encoding phoH homolog polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing phoH homolog polypeptides to screen for antibacterial compounds.

PhoH homolog

The invention provides gbpA polypeptides and DNA (RNA) encoding gbpA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gbpA polypeptides to screen for antibacterial compounds.

GbpA

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Royersford, PA, United States of America

Martin M Rosenberg