Abbvie Biotechnology Ltd

Abbvie Inc.

Abb Vie Deutschland Gmbh & Co. Kg

Martin M Okun

Thomas C Harris

Rebecca S Hoffman

Elliot Keith Chartash

Walid M Awni

Susan K Paulson

William T Barchuk

Joaquin Mario Valdes

Martin Kaul

William G Glass

Jonathan Barker

Yanjun Bao

Yihua Gu

Tom C Harris

Parvez M Mulani

Kenneth B Gordon

Peter Noertersheuser

The invention provides methods and compositions for the treatment of a skin disorder associated with detrimental TNF&#x3b1; activity, such as psoriasis. The invention includes methods for treating a skin disorder associated with detrimental TNF&#x3b1; activity, such as psoriasis, in a subject who has failed or lost response to prior biologic therapy, such as prior administration of etanercept. The invention further provides methods for determining the efficacy of a human TNF&#x3b1; antibody, or antigen-binding portion thereof, for the treatment of a skin disorder associated with detrimental TNF&#x3b1; activity, such as psoriasis.

Methods and compositions for treatment of skin disorders

The invention provides methods, uses and compositions for the treatment of hidradenitis suppurativa. The invention describes methods and uses for treating hidradenitis suppurativa, wherein a TNF&#x3b1; inhibitor, such as a human TNF&#x3b1; antibody, or antigen-binding portion thereof, is used to treat hidradenitis suppurativa in a subject. Also described are methods for determining the efficacy of a TNF&#x3b1; inhibitor for treating hidradenitis suppurativa in a subject.

Methods of treating moderate to severe hidradenitis suppurativa with anti-TNFalpha antibody

Methods of treating moderate to severe hidradenitis suppurativa with anti-TNF-alpha antibodies

The invention provides methods of treating psoriasis in a subject by administering to a subject an antibody capable of binding to the p40 subunit of IL-12 and/or IL-23.

Methods for treating psoriasis using antibodies that bind to the P40 subunit of IL-12 and/or IL-23

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Libertyville, IL, United States of America

Martin M Okun