Dentsply Ih Ab

Astrego Diagnostics Ab

Dentsply Sirona Inc.

Dentsply International Inc.

Wellspect Ab

Martin Lovmar

Ove Öhman

Johan Elf

Özden Baltekin

Mikael Olsson

Niklas Dahlberg

Venkata R S S Mokkapati

Santosh Pandit

Jie Sun

Jan Mikael Utas

Evelina Gustavsson

Michael Read

Petter Hammar

Peter Madlung

Johan Öhman

Lovisa Söderberg

Elias Amselem

ÖZden Baltekin

VRSS Mokkapati

A reusable urinary catheter assembly comprises a storage container defining a cavity, a hydration liquid and a reusable urinary catheter. The hydration liquid includes a disinfection medium and a hydrophilic polymer. The viscosity of the hydration liquid is 40 cP or lower. The reusable urinary catheter includes a shaft, and at least a part of the shaft is provided with a hydrophilic surface. During storage, the shaft is enclosed within the cavity in a storage position. The hydration fluid hydrates and regenerates the hydrophilic surface and disinfects the catheter. The catheter is configured to be repeatedly inserted into and removed from the storage container.

Reusable hydrophilic urinary catheter assembly

Improved urinary catheters are described. One example urinary catheter includes a catheter shaft with an internal lumen, extending between a distal discharge opening and a proximal drainage opening, arranged at a proximal tip of the catheter shaft. An overcoat layer encircles a portion of the catheter shaft, forming a closed deformable fluid filled cavity intermediate the overcoat layer and the outer surface of the shaft. The overcoat layer is elastically deformable to allow for movement of the fluid within the cavity during deployment. At least a portion at the proximal end is arranged to be compressed to a smaller diameter during insertion, and upon continued insertion of the catheter shaft through the urethra into at least the bladder neck, arranged to expand back toward a greater diameter, as the fluid is caused to flow toward the proximal end of the fluid filled cavity.

Urinary catheter for controlled drainage

A microfluidic device () comprises a substrate () having spatially defined and separated cell compartments () configured to accommodate cells. A respective first end () of the spatially defined and separated cell compartments () is in fluid connection with a flow input channel (). The microfluidic device () comprises at least one identification surface () comprising immobilized affinity molecules configured to capture cells of a species or serotype or of a group of species or serotypes.

Microfluidic device for cell characterization

A capturing of target cells from a biological sample is achieved by inducing a flow of the biological sample in a flow channel () of an upstream microfluidic device (). Target cells present in the biological sample are captured in cell channels () of the upstream microfluidic device (). Once at least a minimum number of target cells are captured in the cell channels (), the flow of the biological sample in the flow channel is reduced and are verse flow is applied at the upstream microfluidic device () to release the target cells captured in the cell channels () of the upstream microfluidic device () and enable transfer the target cells into cell channels () of a downstream microfluidic device ().

Cell capture in microfluidic devices

Phenotyping of cells involves loading a biological sample into a microfluidic device () comprising cell compartments () to capture biological material, including target cells, in the sample in the cell compartments (). A subset (A) of the cell compartments () is identified as comprising target cells exhibiting target phenotype characteristic(s) as determined based on monitoring biological material in the cell compartments () prior to addition of a test agent. The biological material is exposed to a test agent and a phenotypic response of the target cells to the test agent is determined based on monitoring target cells in the identified subset (A) of the cell compartments (). The phenotyping of the target cells is thereby not overshadowed by the response of other cells and non-cell material present in the biological sample.

Phenotypic characterization of cells

A sample loading cartridge () for a microfluidic device comprises a cartridge body () with a sample reservoir () configured to house a volume of a liquid sample () and a sample port () in connection with the sample reservoir (). The cartridge () also comprises an output channel () extending from the sample reservoir () and a feedback channel () connected to the sample reservoir () and to the sample port (). The cartridge body () comprises a detection portion () aligned with the feedback channel () to enable detection of any sample () in the feedback channel (). The flow resistance of the feedback channel () is lower than the flow resistance of the output channel () to cause liquid sample () received in the sample port () to enter the feedback channel () with substantially no liquid sample () entering the output channel ().

Sample loading cartridge

A microfluidic device () comprises a substrate () having a flow input channel () in fluid connection with a first fluid port () and a flow output channel () in fluid connection with a third fluid port () and cell channels () disposed between the flow input channel () and the flow output channel (). The cell channels () comprise a respective obstruction () designed to prevent the target cells from passing the respective obstruction () and into the flow output channel (). The microfluidic device () also comprises a pre-filter () with a filter channel () in fluid connection with a first filter port () and pre-filter channels () adapted to accommodate the target cells. A respective first end () of the pre-filter channels () is in fluid connection with the filter channel () and a respective second end () of the pre-filter channels () is in fluid connection with the flow input channel ().

Microfluidic device

An antibacterial device is disclosed that includes a substrate and an antibacterial coating or antibacterial surface being provided on at least a part of the substrate's surface. The antibacterial coating or surface includes Angstrom scale flakes, where the Angstrom scale flakes are arranged in a standing position on the substrate surface and are attached to the substrate surface via edge sides thereof. The Angstrom scale flakes can, for example, be graphene flakes, or graphite flakes having a thickness of a few atom layers. It has been found that such standing flakes are efficient in killing prokaryotic cells but do not harm eukaryotic cells.

Antibacterial coating or surface comprising vertical, standing angstrom scale flakes

An insertion aid for catheter manipulation is disclosed. The insertion aid can be used for urinary catheters, such as hydrophilic urinary catheters for intermittent use. The insertion aid includes first and second plate-like arms arranged overlying each other and with a separation distance there between. The insertion aid also includes a resilient hinge connecting adjacent marginal edges of the plate-like arms together. At least one of the plate-like arms includes a groove on its clamping inner surface for holding a catheter shaft. The groove extends at least partly in the same direction as, and essentially parallel to, the resilient hinge, and is arranged at a distance both from the resilient hinge and from the marginal edge of the plate-like arm. Corresponding catheter set and catheter assembly are also disclosed.

Catheter insertion aid

A urinary catheter and a method of its manufacture are disclosed. The urinary catheter comprises a tubular shaft extending between an insertion end and a discharge end, the tubular shaft being formed of at least two materials having different properties. The materials are arranged substantially separated from each other in distinct zones, wherein at least one of the width and thickness of said zones varies over the length of the tubular shaft, to form two or more uniform sections of the tubular shaft having various relative amounts of said materials, and wherein at least one transition between two such uniform sections is formed by at least one transition section providing a gradual transition between the uniform sections. The catheter can e.g. be produced by intermittent extrusion.

Growing community of inventors

Mölndal, Sweden

Martin Lovmar