Max-delbruck-centrum Fur Molekulare Medizin in Der Helmholtz-gemeinschaft

Julius-maximilians-universitat

Bayerische Julius-maximilians-universitat Wurzburg

Julius-Maximillians-Universität-Würzburg

Julius-mazimillians-universitat Wurzburg, a German University

Julius-maximillians-universitat Wurzburg, a Germany University

Julius-maximilians-universtitat-wurzburg

Pfeiffer Vacuum Gmbh

Julius-maximilians-universitat Wurzburg

Julius-maximilians-universitaet Wuerzburg

Pfeiffer Vacuum Technology Ag

Martin Lohse

Jan Hofmann

Tobias Stoll

Valérie Jahns

Roland Jahns

Florian Bader

Dieter Palm

Viacheslav Nikolaev

Moritz Bünemann

Florian Schneider

Marc Bathe-Peters

Jean-Pierre Vilardaga

Carsten Hoffmann

Paolo Annibale

Michael SCHWEIGHÖFER

Maximilian Birkenfeld

Sebastian SÜDWASSER

Lothar Brückmann

Robert Walz

Daniel Sieben

Peter Vorwerk

Valerie Jahns

A microscope-autofocus device for feedback-controlling a focal position of an imaging system of a microscope apparatus, wherein the imaging system includes a microscope objective, a monitoring beam source for creating a monitoring beam, a detector device for detecting a drift variation of an axial objective distance between the microscope objective and a sample by sensing the monitoring beam directed through the imaging system to the sample and reflected by the sample, and a feedback loop device for controlling the imaging system in dependency on the detected objective distance variation of the microscope objective.

Autofocus-control of a microscope including an electrically tunable lens

The present invention relates to novel &#x3b2;-AR homologous cyclopeptide-mutants comprising only two cysteine residues able to form an intramolecular linkage, to linear peptides that can form these cyclopeptide-mutants and to nucleic acid molecules encoding these cyclopeptide-mutants and linear peptides. Moreover, vectors and recombinant host cells comprising said nucleic acid molecule and a method for producing the disclosed cyclopeptide-mutants are provided. Further provided is a composition comprising the peptides, nucleic acid molecules, vectors or host cells of the invention. The present invention also relates to therapeutic and diagnostic means, methods and uses taking advantage of the peptides of the invention and to means, methods and uses for detecting anti-&#x3b2;-adrenergic receptor antibodies like anti-&#x3b2;-adrenergic receptor antibodies.

[object Object]

Described is a chimeric peptide, comprising, in order, (a) a first detectable label (b) a cAMP binding moiety having only one cAMP binding site and (c) a second detectable label least two detectable labels is describe. The chimeric peptide is useful for direct determination of cAMP concentration in vitro and/or in vivo. Also described are nucleic acids encoding the chimeric peptide, methods of making and modifying the chimeric peptide, a method for determining the cAMP concentration, and kits.

Means and methods for the determination of camp in vitro and in vivo

Embodiments of the present invention provide for novel peptides of use for detection and/or inhibition of anti-&#x3b2;1-adrenergic receptor antibodies. Certain embodiments concern uses of cyclic and/or linear peptides. In other embodiments, the present invention relates to novel peptides of use in diagnostic and/or pharmaceutical compositions. Some embodiments concern diagnosing and/or treating cardiac conditions. Cardiac conditions of the instant invention can concern infectious heart disease, non-infectious heart disease, ischemic heart disease, non-ischemic heart disease, inflammatory heart disease, myocarditis, cardiac dilatation, idiopathic cardiomyopathy, idiopathic dilated cardiomyopathy, immune-cardiomyopathy, heart failure, and any cardiac arrhythmia condition.

Means for the inhibition of anti-&#x3b2;1-adrenergic receptor antibodies

Means for the inhibition of anti-beta1-adrenergic receptor antibodies

The present invention relates to recombinant seven-transmembrane receptor, whereby the amino terminus of said recombinant receptor is located on an extracellular side and the carboxy-terminus is located on an intracellular side of a membrane, comprising at least two detectable labels, whereby a first of said at least two detectable labels is or is located on the carboxy-terminus and whereby a second of said at least two labels is or is located on the first or third intracellular loop or whereby a first of said at least two labels is or is located on the third intracellular loop. Furthermore, nucleic acid molecules encoding said recombinant seven-transmembrane receptors are described as well as vector and host cells comprising the same. Furthermore, the present invention provides for identification and screening methods for molecules or compounds which are capable of modifying the biological end of pharmacological function of seven-transmembrane receptor proteins. Finally, diagnostic compositions comprising the compounds of the present invention as well as kits comprising said compounds are disclosed.

Millisecond activation switch for seven-transmembrane proteins

Growing community of inventors

Würzburg, Germany

Martin Lohse