Sandoz Ag

Martin Langner

Dominic De Souza

Thorsten Wilhelm

Hubert Sturm

Martin Albert

Abhinay C Pise

Wolfgang Felzmann

Sachin Bhuta

Michael Fischer

Joerg Salchenegger

Birgit Endl

Michael Oberhuber

Ronny Huetz

Hans-Peter Spitzenstaetter

Jörg Salchenegger

Hans-Peter SPITZENSTÄTTER

The present invention relates to a highly convergent method for the synthesis and purification of ceftolozane and intermediates starting from 7-aminocephaiosporanic acid (7-ACA).

Process for preparing ceftolozane from 7-aminocephalosporanic acid (7-ACA)

The present invention relates to a process for the preparation of a compound of formula (V), in particular posaconazole, wherein said process comprises the steps of (1) providing a mixture comprising a compound of formula (IV), a protic solvent system, and a suitable base; and (2) heating the mixture of (1) to obtain a mixture comprising the compound of formula (V). 

Process for the preparation of a chiral compound

The present invention relates to a process for the preparation of a hydrogen chloride (HCl) salt of a compound of formula (I) wherein Yand Yare independently F or Cl, preferably F, said compound of formula (I) containing the cis-isomer and the trans-isomer, wherein the process comprises (1) providing the compound of formula (I) comprised in a first suitable solvent; and (2) treating the compound of formula (I) comprised in the first suitable solvent with HCl comprised in a second suitable solvent to obtain the HCl salt of the compound of formula (I). 

Purification of posaconazole and of posaconazole intermediates

A process for the preparation of a chiral compound, in particular posaconazole, wherein the process comprises mixing and reacting the compounds of formula (I) Y&#x2014;NH; of formula (IIa) 0=C&#x2550;N&#x2014;Yand/or of formula (IIb) and of formula (III) in a solvent in any order to obtain a reaction mixture containing a chiral compound of formula (IV) and/or formula (V). 

Process for the preparation of chiral triazolones

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Kundl/Tyrol, Austria

Martin Langner