American Cyanamid Company

Martin L Sassiver

William J McGahren

George A Ellestad

James H Boothe

Janis Upeslacis

Philip R Hamann

Lois M Hinman

Andrew S Tomcufcik

Keith C Murdock

William V Curran

Howard Hancock Newman

Thomas L Fields

A process is described for producing substituted disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 complex.

Antitumor and antibacterial substituted disulfide derivatives prepared

This disclosure describes a method for constructing targeting agent drug conjugates from the family of methyltrithio antibacterial and antitumor agents.

Process for preparing targeted forms of methyltrithio antitumor agents

This disclosure describes disulfide analogs of the family of antibacterial and antitumor agents known collectively as the LL-E33288 complex.

Compounds of the formula: ##STR1## wherein R.sup.1, R.sup.2 and m are defined in the specification are provided. These compounds are useful as antihypertensive agents.

Substituted benz[cd]indol-2-(1H)-ones and use as antihypertensive agents

This disclosure describes a method for constructing carrier-drug conjugates from the family of methyltrithio antibacterial and antitumor agents.

Targeted forms of methyltrithio antitumor agents

Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.

Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and

This disclosure describes a novel process for the synthesis of 5-mercapto-1,2,3-thiadiazoles which are useful as intermediates in the preparation of antibacterial agents.

Derivatives of 3-(formylmethylthio)-propanoate

This disclosure describes compounds of the class of 6-[D-.alpha.-(substituted-coumarin-3-carboxamido)phenylacetamido ]penicillanic acids which possess antimicrobial activity.

7-[D.alpha.-(Coumarin-3-carboxamido)arylacetamido]-cephalosporanic acids

This disclosure describes compounds of the class of 6-[D-.alpha.-(benzocoumarin-3-carboxamido)phenylacetamido] penicillanic acids which possess antimicrobial activity.

6-[D-.alpha.-(Coumarin-3-carboxamido)arylacetamido]-penicillanic acids

This disclosure describes compounds of the class of 6-[D-.alpha.-(substituted-coumarin-3-carboxamido)phenylacetamido]penicilla nic acids which possess antimicrobial activity.

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Spring Valley, NY, United States of America

Martin L Sassiver