Mount Sinai Hospital Corporation

Martin L Breitman

Daniel J Dumont

Janet Rossant

Terry P Yamaguchi

Gerard G Gradwohl

Jo-Ann Breitman

Novel receptor tyrosine kinase protein and isoforms thereof which are expressed in cells of the endothelial lineage, and DNA segments encoding the novel protein and isoforms thereof are disclosed. Methods for identifying ligands which are capable of binding to the receptor protein and methods for screening for agonist or antagonist substances of the interaction of the protein and a ligand are also disclosed.

Receptor tyrosine kinase

A novel transcriptional regulatory element which is capable of directing expression of a gene specifically in cells of the endothelial lineage. The transcriptional regulatory element may be used to target expression of a gene in cells of the endothelial lineage.

Growing community of inventors

Willowdale, Canada

Martin L Breitman