Cardiome Pharma Corp.

Eprova Ag

Correvio International Sàrl

Martin Kurz

Bertrand M C Plouvier

Doug Ta Hung Chou

Tao Sheng

Grace Jung

Anthony G M Barrett

Alfred Hedinger

Pirmin Ulmann

Lewis Siu Leung Choi

Marco Silvio Passafaro

Daniel Moeckli

Heinrich Bollinger

Hans Rudolf M&uuml;ller

Peter Schwaninger

Betrand Mc Plouvier

Marco S Passafaro

Anthony GM Barrett

Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.

Synthetic process for aminocyclohexyl ether compounds

Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed. 

With the present method, a process which can be employed industrially can be used for the first time for the direct production of aminocyanoacetamide. The method is based on the reaction of cyanoacetamide with nitrites to form nitrosocyanoacetamide at a pH of around 2 and on the subsequent catalytic hydrogenation of nitrosocyanoacetamide to form aminocyanoacetamide.

Method of producing aminocyanoacetamide

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Schaffhausen, Switzerland

Martin Kurz