Hoffmann-la Roche Inc.

Tillotts Pharma Ag

F. Hoffmann-la Roche Ag

Martin Kuentz

Felipe José Oliveira Varum

Roberto Carlos Bravo Gonzaléz

Nicole Wyttenbach

Alfred Ross

Jochem Alsenz

Carla Garofalo

Wiebke Svea Saal

Dieter Roethlisberger

Gisela Ledergerber

Jan Kendall De Kruif

The present invention provides novel, solid or liquid pharmaceutical preparations comprising a basic or neutral, low molecular weight active pharmaceutical ingredient and the polymer Eudragit&#xae; EPO, optionally together with additional pharmaceutically acceptable excipients. The present preparations are for oral or topical administration.

Pharmaceutical compositions for basic or neutral, low molecular weight compounds

The present invention relates to microgel particles containing nanotubes loaded with an active pharmaceutical ingredient, a process for their preparation and a pharmaceutical composition comprising the same.

Microgel particles containing nanotubes loaded with an active pharmaceutical ingredient

A pharmaceutical composition for oral administration of an active compound having a bioavailability of 20% or less. The composition comprises, based on its total weight, from 0.01% to about 15% (w/w) of said active compound molecularly dissolved in the composition, from 30 to 80% (w/w) of an edible lipid matrix and from 1 to 20% (w/w) of an edible emulsifier, the ratio between the dose weight of the active compound and its solubility in the composition being equal to or greater than 0.6 ml. The high percentage of fat (30-80%) enables a considerable increase the amount of the drug that is molecularly dispersed in the dosage form, thus allowing a significant reduction in the number of unit doses that must be taken daily-by patients.

Galenic composition for low bioavailability medicaments

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Muttenz, Switzerland

Martin Kuentz