Hoechst Aktiengesellschaft

Martin Kramer

Dominique Tripier

Paul Habermann

Peter Crause

Rainer Obermeier

Klaus Sauber

Matthias Scharf

Joachim Engels

The present invention relates to hirudin derivatives which are formed from hirudin or the physiologically acceptable salt thereof and a carrier, to a process for the preparation thereof, and to the use thereof as thrombin inhibitor.

Hirudin derivatives with delayed action

Thrombin inhibitors from the hirudin family which differ from the previously known hirudins by mutation in the protein chain, and a process for their preparation are described. The novel hirudins are distinguished by a high specific activity, high stability and good pharmacokinetics.

Isohirudins

The invention relates to a polypeptide of the formula ##STR1## in which R represents phenoloic hydrogen or a phenolic ester group and m, n, X, Z, A, B, C, D, E, F, G, I and J have the meanings given, and in which the 6 Cys radicals are linked in pairs via disulfide bridges, processes for the preparation or isolation thereof, their use and agents containing them.

Novel polypeptides with a blood coagulation-inhibiting action, processes

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Wiesbaden, Germany

Martin Kramer