Membrana Gmbh

3m Innovative Properties Company

Akzo Nobel N.v.

Martin König

Bodo Von Harten

Horst-Dieter Lemke

Frank Wiese

Wolfgang Ramlow

Manfred Martin

Hans-Gunter Breidohr

Frank Heuser

Bernhard Krautwurst

The invention relates to a method for reducing the number of leukocytes in blood through treating the blood in an arrangement of a plurality of fibers based on organic polymers, whereby the blood is channeled along the fibers and whereby the reduction in leukocytes from the blood occurs essentially through adsorption on the fibers, characterized in that the plurality of fibers based on organic polymers is fixed in a housing with an inlet arrangement and an outlet arrangement, and that the blood is channeled via the inlet arrangement into the housing, flows through the housing with the plurality of fibers made from organic polymers, and exits the housing via the outlet arrangement, that the arrangement of the fibers shows a high degree of order, that the blood flows along the external surface of the fibers, and that the fibers cause a generation of the complement activation product C5a in a concentration of at least 10 &#x3bc;g per mof fiber surface.

Method for the elimination of leukocytes from blood

A device for reducing the number of leucocytes in blood comprising a plurality of hollow fibers based on organic polymers, whereby the hollow fibers have a lumen and a wall surrounding the lumen, said wall having an internal surface facing the lumen and an external surface, whereby the hollow fibers are arranged in a cylindrical housing with an inlet arrangement and an outlet arrangement and whereby an outer space is formed between the hollow fibers and the housing, which space is accessible for a fluid via the inlet arrangement and the outlet arrangement, characterized in that only the external surfaces of the hollow fibers are accessible for a fluid, that the lumina of the hollow fibers are not accessible for a fluid, that the arrangement of the hollow fibers shows a high degree of order and that the hollow fibers based on organic polymers cause a generation of the complement activation product C5a in a concentration of at least 10 &#x3bc;g per mof fiber surface.

Device for removing leukocytes from blood

Process for removal of lumen fillers and other soluble residues from

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Düsseldorf, Germany

Martin König