Pari Gmbh Spezialisten Fur Effektive Inhalation

Paul Ritzau Pari Werk Gmbh

Pari Pharma Gmbh

Breath Therapeutics Gmbh

Paul Rizau Pari-werk Gmbh

Pari Pharma Gmbh Spezialisten Für Effektive Inhalation

Pari Pharama Gmbh

Pari Gmbh Spezialisten Fur Effetive Inhalation

Kamada Ltd.

Martin Knoch

Thomas Gallem

Manfred Keller

Robert Waldner

Kevin Stapleton

Oliver Denk

Andreas Lintl

Stefan Jaser

Eric Wunderlich

Roland Stangl

Stephan Brugger

Markus Urich

Dieter Kohler

Matthias Remke

Shabtai Bauer

Zhengfeng Zhang

Ales Blaha-Schnabel

Erik Wunderlich

Rainer Liening-Ewert

The invention relates to an aerosol delivery device comprising an aerosol generator for generating an aerosol in the aerosol delivery device, a sensor configured to detect a use of the aerosol delivery device for aerosol treatment, and a controller configured to deactivate the aerosol generator if no use of the aerosol delivery device for aerosol treatment is detected by the sensor. Further, the invention relates to a method for operating an aerosol delivery device, comprising the steps of operating an aerosol generator for generating an aerosol in the aerosol delivery device, detecting a use of the aerosol delivery device for aerosol treatment by means of a sensor, and deactivating the aerosol generator by means of a controller if no use of the aerosol delivery device for aerosol treatment is detected by the sensor.

Aerosol delivery device and operating method for the aerosol delivery device

The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonary chronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.

Cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection

The invention relates to an aerosol delivery device () comprising an aerosol generator () for generating an aerosol in the aerosol delivery device (), a sensor () configured to detect a use of the aerosol delivery device () for aerosol treatment, and a controller () configured to deactivate the aerosol generator () if no use of the aerosol delivery device () for aerosol treatment is detected by the sensor (). Further, the invention relates to a method for operating an aerosol delivery device (), comprising the steps of operating an aerosol generator () for generating an aerosol in the aerosol delivery device (), detecting a use of the aerosol delivery device () for aerosol treatment by means of a sensor (), and deactivating the aerosol generator () by means of a controller () if no use of the aerosol delivery device () for aerosol treatment is detected by the sensor ().

The invention relates to cyclosporine formulations for use in the prevention or treatment of pulmonary chronic graft rejection. In particular, the invention provides a cyclosporine liquid formulation for use as an aerosol for inhalation in a method of preventing or treating pulmonarychronic graft rejection in single lung transplanted patients. The formulation is preferably administered once or twice daily. The formulation may be aerosolized with a nebulizer that comprises features for monitoring the time, date and duration of inhalation by the patient, in order to monitor patient adherence. The formulation according to the invention may be combined with standard immunosuppressants and corticosteroids.

Chip card

Control unit

Nebulizer

An inhalation nebulizer () includes an aerosol generator () that has a diaphragm () vibrated by a vibration generator (). The inhalation nebulizer () includes a liquid storage container () that is in fluid contact with the diaphragm (). A liquid contained in the storage container () is atomized into a mixing chamber () through openings in the diaphragm and can subsequently be inhaled by a patient.

Inhalation nebulizer

Metering aerosol dispensing device comprising an aerosol container ( ); a nozzle ( ) that is arranged in a nozzle body ( ), whereby the aerosol is dispensed via said nozzle when the aerosol container ( ) is pushed against the body ( ) of the nozzle once the metering aerosol dispensing device is actuated; a meter ( ) that counts the number of times that the metering aerosol dispensing device is actuated; and an actuating device ( ) that enables the meter ( ) to move forward when the metering aerosol dispensing device is actuated. The invention is characterized in that the actuating device ( ) is designed and arranged in the metering aerosol dispensing device in such a way that the body ( ) of the nozzle is accomodated in the interior of the actuating device ( ) and the nozzle ( ) is released in order to produce aerosol in an unrestricted manner.

Actuating device for meters and metering aerosol dispensing device with an actuating device for meters

Electronic inhaler and control unit

The invention describes a mouthpiece for an inhalation therapy unit wherein an aerosol for inhalation is prepared for a patient, said mouthpiece comprising a substantially tubular base ( ), in the wall of which an orifice ( ) is formed, and a flat, elastic valve member ( ), which is adapted in dimension and shape to the orifice ( ) for the closing thereof and which is secured to the mouthpiece in such a manner that during an inspiration process through the mouthpiece the orifice ( ) is closed and during an expiration process directed into the mouthpiece the orifice ( ) is opened. According to the invention, at least one enlarged contact surface ( ) is provided at the orifice ( ) for the accumulation and holding of an amount of liquid by adhesion. This contact surface is established both by an outwardly directed collar ( ) surrounding the orifice and by a narrow bar ( ) which extends into the orifice ( ) for example transversely through the center of the orifice in longitudinal direction of the mouthpiece or transversely across the mouthpiece.

Mouth piece for inhalation therapy units

The present invention relates to a meter, especially a meter for metering aerosol devices, basically consisting of four disk units that are arranged in a parallel position and located on the same axis.

Meter

Propellant mixtures and medicament aerosols which contain them are described for micronizing medicaments for pulmonary use. The propellant mixture is in a subcritical state and contains at least one component from a first class of propellant gasses and at least one component from a second class of propellant gasses. The first class includes propellant gasses with an evaporation enthalpy of 200 kJ/kg or less at 25&deg; C. and a vapor pressure of 20 bars or more at 25&deg; C., and the second class includes propellant gasses with an evaporation enthalpy of 300 kJ/kg or more at 25&deg; C. and a vapor pressure of 10 bars or less at 25&deg; C. By using this propellant mixture in a medicament aerosol, micronized medicaments are obtained in which approximately 80% by weight of the generated particles have less than 8 &mgr;m diameter.

Propellant mixtures and aerosols for micronizing medicaments with compressed gas

A limiting valve (,) is provided in an inhalation therapy unit with a valve member (,) which closes an air through opening (,) in the idle state and corresponding to the pressure difference occurring over the valve opens same substantially proportionally up to a threshold value. If the threshold value is exceeded, the valve member (,) abuts against a limiting member (,) which limits the movement of the valve member (,) and the air passage orifices (,) of which are partially closed by the valve member (,) so that air can only flow through the air passage auxiliary orifices remaining free. In this manner the patient using the inhalation therapy unit is urged to breath in the range below the threshold value, as his respiration above the threshold value is opposed by a considerably higher resistance.

Inhalation therapy unit with a valve for limiting the inspiration flow

Growing community of inventors

Berg, Germany

Martin Knoch