Universitéde Strasbourg

Harvard College

Centre National De La Recherche Scientifique

Université Louis Pasteur De Strasbourg

Le Centre National De La Recherche Scientifique

Karplus, Martin

Winssinger, Nicolas

Barluenga, Sofia

Martin Karplus

Nicolas Winssinger

Sofia Barluenga

Diane Marie Joseph-McCarthy

George M Whitesides

James Hogle

James Li-wen Cheh

James M Hogle

Victor G Ovchinnkov

Lyle D Isaacs

The present invention features polypeptides which inhibit dimerization of small multidrug resistance transporters including a stabilized &#x3b1;-helix, and the use of such polypeptides in the treatment of bacterial infections.

Stabilized polypeptides and uses thereof

Disclosed are macrocyclic compounds of formulae I, I', II, II&#x2032;, III, III&#x2032;, IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, and methods and uses comprising the compounds for the treatment of diseases mediated by kinases and Heat Shock Protein 90 HSP90.

Synthesis of resorcylic acid lactones useful as therapeutic agents

Disclosed are macrocyclic compounds of formulae I-V, which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.

Macrocyclic compounds useful as inhibitors of kinases and HSP90

The present invention provides structure-based combinatorial libraries of compounds containing the functional group minima of picornaviruses including poliovirus and rhinovirus. The libraries can be used to screen for therapeutical antiviral compounds, e.g., anti-picornaviral capsid-binding compounds.

Anti-picornaviral ligands via a combinatorial computational and synthetic approach

Structure based design of capsid stabilizing or antiviral agents

Growing community of inventors

Cambridge, MA, United States of America

Martin Karplus