Other

Smithkline Beecham Corporation

Affinium Pharmaceuticals, Inc.

Martin Karl Russell Burnham

John Edward Hodgson

Michael Terence Black

Michael Arthur Lonetto

Richard Lloyd Warren

Richard Oakley Nicholas

Martin M Rosenberg

Raymond Winfield Reichard

Christopher Michael Traini

Judith M Ward

Julie M Pratt

Leslie Marie Palmer

David Justin Charles Knowles

Jason Craig Fedon

Min Wang

Deborah Dee Jaworski

Christine Marie Debouck

Jeffrey L Mooney

Nicola Gail Wallis

Yi Yi Zhong

Yi Y Zhong

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

The invention provides MurC polypeptides and polynucleotides encoding MurC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurC polypeptides to screen for antibacterial compounds.

MurC

The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.

ribB

Novel cell surface protein polypeptides and DNA (RNA) encoding such novel cell surface protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel cell surface protein for the treatment of infection, particularly bacterial infections. Antagonists against such novel cell surface protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel cell surface protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding cell surface protein family and for detecting the polypeptide in a host.

Cell surface protein compounds

The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.

Polynucleotides encoding GTP cyclohydrolase II (RIBA)

The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.

ribG

GTP cyclohydrolase II (RIBA)

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Barto, PA, United States of America

Martin Karl Russell Burnham