Smithkline Beecham Corporation

Other

Affinium Pharmaceuticals, Inc.

Martin Karl Russel Burnham

John Edward Hodgson

Patrick Vernon Warren

Michael Arthur Lonetto

Martin M Rosenberg

Judith M Ward

Michael Terence Black

Richard Oakley Nicholas

David Justin Charles Knowles

Raymond Winfield Reichard

Julie M Pratt

Sanjoy Biswas

Richard Lloyd Warren

Magdalena Zalacain

Karen Anne Ingraham

Alison Francis Chalker

David John Holmes

Andrew P Fosberry

James Raymond Brown

Christopher Michael Traini

Min Wang

Deborah Dee Jaworski

Elizabeth J Lawlor

Chi Young So

Elizabeth Jane Lawlor

John E Hodgson

Stephanie Van Horn

Lisa Kathleen Shilling

Thomas B Mathie

Daniel Robert Gentry

Robert King Stodola

Stephen Dudley Holmes

Phillip N Zarfos

Chi Yong So

Jamie M Pratt

Raymond Winfield Riechard

Simon J Foster

Robert H Reid, Jr

The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.

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The invention provides spo0J1 polypeptides and polynucleotides encoding spo0J1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo0J1 polypeptides to screen for antibacterial compounds.

Polynucleotide encoding spo0J1 of Staphylococcus aureus

The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.

Compounds

The invention provides Fibronectin Binding Protein polypeptides and DNA (RNA) encoding Fibronectin Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Fibronectin Binding Protein polypeptides to screen for antibacterial compounds.

Fibronectin binding proteins

The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.

Member of ATP dependent protease family, clpL

The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.

inFB

spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.

Spo-rel

The invention provides M Protein polypeptides and DNA (RNA) encoding M Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing M Protein polypeptides to screen for antibacterial compounds.

M protein

The invention provides Fibronection Binding Protein polypeptides and DNA (RNA) encoding Fibronection Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Fibronection Binding Protein polypeptides to screen for antibacterial compounds.

Fibronectin binding protein compounds

Prokaryotic polynucleotides polypeptides and their uses

The invention provides mecB polypeptides and polynucleotides encoding mecB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mecB polypeptides to screen for antibacterial compounds.

MecB

The invention provides Glutamine Transport ATP-Binding Protein polypeptides and DNA (RNA) encoding Glutamine Transport ATP-Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glutamine Transport ATP-Binding Protein polypeptides to screen for antibacterial compounds.

Polynucleotides encoding a novel glutamine transport ATP-binding protein

The invention provides pai polypeptides and DNA (RNA) encoding pai polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pai polypeptides to screen for antibacterial compounds.

The invention provides yhxB polypeptides and polynucleotides encoding yhxB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing yhxB polypeptides to screen for antibacterial compounds.

yhxB

The invention provides nrdD polypeptides and DNA (RNA) encoding nrdD polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nrdD polypeptides to screen for antibacterial compounds.

Growing community of inventors

Norristown, PA, United States of America

Martin Karl Russel Burnham