Smithkline Beecham Corporation

Affinium Pharmaceuticals, Inc.

Martin Karl Burnham

John Edward Hodgson

Michael Arthur Lonetto

David Justin Knowles

Michael Terence Black

Richard Oakley Nicholas

Judith M Ward

Martin M Rosenberg

Patrick Vernon Warren

Raymond Winfield Reichard

Julie M Pratt

Richard Lloyd Warren

Christopher Michael Traini

Leslie Marie Palmer

Jason Craig Fedon

Robert King Stodola

Min Wang

Deborah Dee Jaworski

Sanjoy Biswas

Ian Chopra

Ian Alfred Critchley

Elizabeth Jane Lawlor

James Raymond Brown

Magdalena Zalacain

David John Holmes

Lisa Kathleen Shilling

Karen Anne Ingraham

Daniel Robert Gentry

Howard Kallender

Christine Marie Debouck

Alison Francis Chalker

Andrew P Fosberry

Jeffrey L Mooney

Stephen Dudley Holmes

Elizabeth J Lawlor

Yi Yi Zhong

John E Hodgson

Chi Young So

Thomas B Mathie

Robert H Reid

Anna Lisa Lenox

Phillip N Zarfos

Richard Oakly Nicholas

This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Compounds

The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.

Era of Streptococcus pneumoniae

The invention provides sugar kinase polypeptides and DNA (RNA) encoding sugar kunase polypepties and methods for producing such polypeptides by recombinant techniques. Also provided are methods or utlizng sugar kinase polypeptides to screen for antibacterial compounds.

Sugar kinase

The invention provides gidB polypeptides and polynucleotides encoding gidB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing gidB polypeptides to screen for antibacterial compounds.

GidB

The invention provides Glucose 6-Phosphate Dehydrogenase gene polypeptides and DNA (RNA) encoding Glucose 6-Phosphate Dehydrogenase gene polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glucose 6-Phosphate Dehydrogenase gene polypeptide for the protection against infection, particularly bacterial infections.

Polynucleotides encoding the glucose 6-phosphate dehydrogenase of

The invention provides mecB polypeptides and polynucleotides encoding mecB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing mecB polypeptides to screen for antibacterial compounds.

mecB

The invention provides infB polypeptides and polynucleotides encoding in polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing infB polypeptides to screen for antibacterial compounds.

infB

The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.

Histidinol dehydrogenase

Novel fibronectin binding protein B polypeptides and DNA (RNA) encoding such novel fibronectin binding protein B and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel fibronectin binding protein B for the treatment of infection, particularly bacterial infections. Antagonists against such novel fibronectin binding protein B and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel fibronectin binding protein B nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding novel fibronectin binding protein B family and for detecting the polypeptide in a host.

Fibronectin binding protein B compounds

Fibronectin binding protein; monoclonal antibody and their use in

The invention provides Glucose Kinase polypeptides and DNA (RNA) encoding Glucose Kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Glucose Kinase polypeptides to screen for antibacterial compounds.

Glucose kinase from Streptococcus pneumoniae

The invention provides 3-DEHYDROQUINATE SYNTHASE polypeptides and DNA (RNA) encoding 3-DEHYDROQUINATE SYNTHASE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing 3-DEHYDROQUINATE SYNTHASE polypeptides to screen for antibacterial compounds.

3-dehydroquinate synthase

Novel cell surface protein polypeptides and DNA (RNA) encoding such novel cell surface protein and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel cell surface protein for the treatment of infection, particularly bacterial infections. Antagonists against such novel cell surface protein and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel cell surface protein nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding cell surface protein family and for detecting the polypeptide in a host.

Cell surface protein compounds

The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.

RibG

The invention provides sugar kinase polypeptides and DNA (RNA) encoding sugar kinase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing sugar kinase polypeptides to screen for antibacterial compounds.

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Norristown, PA, United States of America

Martin Karl Burnham