Glactone Pharma Development Ab

Respiratorius Ab

Everest Biosciences, Inc.

Heraeus Kulzer Nordic Ab

Respiratorious Ab

Arcede Pharma Ab

Heraeus Kulzer Gmbh

Oncorel Ab

Martin Johansson

Olov Sterner

David Wensbo

Maria Dalence

Rikard Larsson

Jörgen Toftered

Jenny Persson

Viveca Thornqvist Oltner

Kristofer Frick

Ritha Gidlöf

Eduardo Muñoz

Anders Falk

Kristofer Svensson

Viveca Thornqvist Otlner

Eduardo MUÑOZ

Viveca Thornqvist-Oltner

The invention relates to novel molecules having the general formula (I), and which molecules are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma inflammation and/or vasoconstriction, e.g. hypertension. 

Bronchodilating hetero-linked amides

Disclosed are sulfonamide analogues of galiellactone of formula (I) as STAT3-inhibitors for use in the treatment of a STAT3 signaling related disorder, e.g. solid cancers, hematological cancers, benign tumors, hyperproliferative diseases, inflammations, autoimmune diseases, graft or transplant rejections, delayed physiological function of grafts or transplants, neurodegenerative diseases and viral infections. The sulfonamide comprises a cyclic substituent. 

Sulfonamide analogues of galiellalactone

Prodrugs of galiellactone, and derivatives thereof, are provided by reacting the parent compound, e.g. galiellactone, with a thiol. Such drugs may be administered orally to treat cancer and other proliferative diseases.

Tricyclic prodrugs

Prodrugs (I) and (Ia) of galiellactone, and derivatives thereof, are provided by reacting the parent compound, e.g. galiellactone, with a thiol. Such drugs may be administered orally to treat cancer and other proliferative diseases. 

Compounds and a method for imaging myocardial perfusion, including administering to a patient a compound linked to an imaging moiety, wherein the compound binds MC-1, and scanning the patient using diagnostic imaging. Kits including the compound or precursor compounds linked or not linked to an imaging moiety are also described.

Diagnostic kit

Contrast agent for imagining myocardial perfusion

The present invention discloses novel compounds useful for the inhibition of IL-6/STAT signaling and/or PI3K/NF-&#x3ba;B signaling in the treatment of associated diseases or conditions, e.g. cancer. A pharmaceutical composition comprising such novel compounds, its use and a method thereof, is also disclosed.

Tricyclic lactones for treatment of cancer

The disclosure describes compounds of formula I, wherein the wedged bonds, R, R, R, R, R, R, R, R, R, R, R, R, R, R, R, X and Y have meanings given in the description, and pharmaceutically-acceptable salts thereof; and methods of using such compounds useful in the treatment of cancer and conditions affected by inhibition of angiogenesis. Also provided, are processes for the preparation of formula I, by reacting formula I with other compounds; and processes for the preparation of a pharmaceutical formulation by bringing into association, a compound of formula I, with therapeutic agents and/or a pharmaceutically-acceptable adjuvant, diluent, or carrier. 

Indolyl-substituted pyrazino[1,2-b]isoquinolines for cancer treatment

The present disclosure provides a dental bridge intermediary structure () comprising a superstructure () and a connection piece (), as well as connection piece for a dental bridge intermediary structure (). A method for producing a dental bridge superstructure () is also provided.

Dental bridges and superstructures, and methods for manufacturing thereof

Indolyl-substituted pyrazino-quinolines and their use for the treatment of cancer

The invention relates to novel compounds having the general formula (I), and which compounds are useful to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma.

Bronchodilating diazaheteroaryls

The invention relates to novel compounds having the general formula (I), and which compounds are useful to manufacture a medicament to treat a disorder or disease characterized by bronchoconstriction, e.g. COPD and asthma, and vasoconstriction, e.g. hypertension.

Growing community of inventors

Helsingborg, Sweden

Martin Johansson