American Cyanamid Company

Other

American Cyanamid

Martin J Weiss

Robert E Schaub

Charles V Grudzinskas

Middleton B Floyd, Jr

Karel F Bernady

John F Poletto

Sow-Mei L Chen

Middleton Brawner Floyd

Gerald J Siuta

Allan Wissner

Hwei-Ru Tsou

Philip R Hamann

William J McGahren

William A Hallett

Lois M Hinman

Irwin J Hollander

Ryan Holcomb

Sow-Mei Lai Chen

Harry M Meyer, Jr

Charles V Gredeinskas

Sow-mei C Chen

This invention describes carrier-drug conjugates prepared from disulfide analogs of the calicheamicin family of potent antitumor antibiotics and their derivatives, as well as similar analogs from related antitumor antibiotics such as the esperamicins. The carrier can be an antibody, growth factor, or steroid which targets an undesired population of cells, such as those of a tumor. Whole protein carriers as well as their antigen-recognizing fragments and their chemically or genetically manipulated counterparts are useful for the targeting portion of the conjugates. This invention includes compounds required for the synthesis of these conjugates, appropriate pharmaceutical compositions of the carrier-drug conjugates, and their method of use.

Process for preparing conjugates of methyltrithio antitumor agents

Conjugates of methyltrithio antitumor agents and intermediates for their

Linkers useful for the synthesis of conjugates of methyltrithio

Enediyne derivatives useful for the synthesis of conjugates of

Selective suppression of B-lymphocytes in mammals is accomplished by treatment with an adequate amount of antibody to a mature B-lymphocyte surface marker.

Suppression of B-lymphocytes in mammals by administration of

This disclosure describes novel 15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion.

15-deoxy-16-hydroxy-16-substituted prostanoic acids and congeners

This disclosure describes 11-deoxy-11-substituted members of the E.sub.2, F.sub.2, E.sub.1, F.sub.1, dihydro E.sub.1 and dihydro F.sub.1 prostaglandin series which are useful as hypotensive agents and as anti-ulcer agents.

11-Deoxy-11-substituted prostaglandins of the E and F series

This disclosure describes novel 15-deoxy-16-hydroxy-16- substituted prostanoic acids and congeners thereof having utility as bronchodilators as hypotensive agents, and as agents for the control of excessive gastric secretion, and particularly, alkyl esters, such as the methyl ester, of such acids.

15-Deoxy-16-hydroxy-16-vinyl and cyclopropyl substituted prostanoic

15-Deoxy-16-hydroxy-16-substituted prostanoic acids and congeners

11-Cyano-prostaglandins of the F-series

This disclosure describes certain 11-hydroxy and 11-deoxy-9-keto(or hydroxy)-prostanoic acid derivatives useful as bronchodilators, anti-ulcer agents, or as intermediates.

Novel hydroxy substituted prostanoic acids, esters, congeners,

This disclosure describes novel 16-aryloxy-17,18,19,20-tetranoprostanoic acids and derivatives thereof useful as bronchodilators and as hypotensive and contraceptive agents.

16-Aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives

This disclosure describes novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives thereof useful as bronchodilators and as hypotensive and contraceptive agents.

Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives

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Oradell, NJ, United States of America

Martin J Weiss