Vectura Gmbh

Ablynx N.v.

Vectura Delivery Devices Limited

Activaero Gmbh

Martin Huber

Tobias Kolb

Bernhard Muellinger

Bernhard Müllinger

Monika Hartmann

Erik Depla

Koen Allosery

Juliane Schick

William C Zimlich

Tobias Hoffmann

Jana Strixner

Ulf Krueger

Ian Mahaffy

Martin Christoph Heiss

Maria-Laura Sargentini

Sebastian Schwendner

Tobias Hoffman

Massimiliano Germani

Raimund Johannes Gleixner

Jana Vogel

Bernhard MÜLLINGER

The present invention provides a refillable container () for use with a nebulizer device having an aerosol generator comprising a transducer body and a membrane having pores, the container having an opening being fillable with a cleaning liquid (), wherein the opening is sized and shaped to fit onto the transducer body, so that the container is held in place on the nebulizer device and the membrane is immersed in the liquid inside the container. The invention also provides a pack comprising a multi-day supply of a drug, one or more cleaning liquids and one or more containers; and a method for cleaning the membrane of a nebulizer device using the container.

Container for cleaning the membrane of a nebulizer

The invention relates to a mixing channel for an inhalation device, and in particular to a mixing channel with improved injection and mixing properties for injecting and mixing a liquid drug into an air flow streaming in the mixing channel, thereby producing an aerosol to be inhaled by a patient. One aspect of the invention relates to a mixing channel for an inhalation device, comprising an inlet opening, an outlet opening, and an injection zone located between the inlet opening and the outlet opening, wherein the injection zone has a longitudinal center axis, wherein the injection zone comprises (a) a built-in nebulizer, or (b) a detachable nebulizer, or (c) a member adapted to receive a detachable nebulizer, wherein the effective cross sectional area of the mixing channel in a plane perpendicular to the longitudinal center axis is smaller in the injection zone than upstream of the injection zone.

Mixing channel for an inhalation device and inhalation device

The invention relates to a dosing system for an inhalation device which is capable of aliquoting a precise and accurately metered volume from a larger pre-defined fill volume. The dosing system comprises a filling chamber for receiving a liquid to be aerosolized, the filling chamber having a lateral wall, an inlet opening and an outlet opening with a closing means () for closing the outlet opening. The dosing system further comprises an overflow chamber surrounding the inlet opening of the filling chamber and a plunger which can be inserted, at least partially, into the filling chamber, and which sealingly contacts the lateral wall such as to displace liquid from said filling chamber upon insertion, and push a metered volume of the liquid out from the filling chamber through the outlet opening and feed it to the nebulizing means of the inhalation device.

Dosing system for an inhalation device

Methods are provided for the treatment of RSV infections in young children. More specifically, methods are provided wherein polypeptides that bind F protein of hRSV and that neutralize RSV infection are administered to the lungs of young children at specific dose regimens.

Methods of treating RSV infections

An inhalation device, assembly or system can include a kit and a pharmaceutical composition. The device can be adapted for administering therapeutic aerosols to pediatric patients, including neonates, infants or toddlers. The device can further include a vibrating mesh aerosol generator that can be insertable into a flow channel of the inhalation device through a lateral opening, and a valved face mask. The device can be connectable to a gas source through which a gas, such as oxygen, can be received into the flow channel at a low flow rate.

Inhalation device for use in aerosol therapy of respiratory diseases

The invention provides an inhalation device for enabling a user to inhale at a desired inspiratory flow rate and/or pressure, comprising a feedback system configured to indicate to a user by means of a signal during an inhalation maneuver whether an inhalation parameter, such as the inspiratory flow rate, is within a predefined target range. The signal may be an optical or a non-optical signal, such as a light signal, an acoustic signal, or a tactile signal.

Inhalation device with feedback system

Mobile inhaler device

An inhalation device having a base unit, a mouthpiece, and an aerosol head is provided. The base unit has an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece has two segments: a first segment which is insertable into the groove of the base unit and has an air inlet opening and a lateral opening for receiving an aerosol generator and a second segment with an aerosol outlet. The aerosol head has an aerosol generator, a liquid reservoir, and key lock member(s) complementary to those of the base unit. The base unit, mouthpiece and aerosol head are connectible with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.

Inhalation device for use in aerosol therapy

A device for the flow rate limitation at low differential pressures, in particular for the limitation of the inhalation volume flow during the inhalation of therapeutic aerosols, comprising a housing with at least an inlet opening, at least an outlet opening and a flow channel arranged therebetween, wherein the flow channel is restricted by a flexible wall extending along the flow channel, characterized in that the flexible wall has a control area of less than 100 mm.

Device for flow rate limitation at low differential pressures

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Furstenfeldbruck, Germany

Martin Huber