Biogen Ma Inc.

Martin Himmelbauer

Zhili Xin

John Howard Jones

Michael A Dechantsreiter

Michael Luzzio

Michael J Luzzio

Provided are compounds of Formula (I): including compounds of Formulas (II), (III) and (IV), wherein X, R, R, Rand n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).

ASK1 inhibiting agents

Provided are compounds of Formula (I): Formula (I), including compounds of Formulas (II), (III), (IV), (V) and (VI), wherein X, R, R, R, Rand n are as defined herein, and pharmaceutically acceptable salts thereof, and methods for their use and production. These compounds can be useful, e.g., in the treatment of disorders responsive to the inhibition of apoptosis signal-regulating kinase 1 (ASK1).

Provided are compounds of Formulas (I'), (I), (II&#x2032;) and (II), or pharmaceutically acceptable salts thereof, and methods for their use and production.

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Cambridge, MA, United States of America

Martin Himmelbauer