Zedira Gmbh

Dr. Falk Pharma Gmbh

Martin Hils

Uwe Gerlach

Rudolf Wilhelm

Roland Greinwald

Ralf Pasternack

Wolfgang Mohr

Johannes Weber

Christian Büchold

Christian Buchold

Bernhard Tewes

Martin Stieler

Christian BÜCHOLD

The invention relates to a compound of general formula (I) as novel inhibitor of blood coagulation factor XIII, methods for synthesis thereof and to use thereof for the prophylaxis or treatment of diseases associated with blood coagulation factor XIII. 

Inhibitors of blood coagulation factor XIII

The invention relates to the compound of general formula (I) as novel inhibitors of transglutaminases, to methods for producing the inventive compounds, to pharmaceutical compositions containing said inventive compounds and to their use for the prophylaxis and treatment of diseases associated with transglutaminases.

Inhibitors of transglutaminases

The invention relates to pyridinone derivatives of general formula (I) as inhibitors of tissue transglutaminase, to methods for producing the pyridinone derivatives, to pharmaceutical compositions containing said pyridinone derivatives and to their use for the prophylaxis and treatment of diseases associated with tissue transglutaminase.

Derivatives of pyridinone as inhibitors for tissue transglutaminase

The present invention relates to the diagnosis of disorders or dysfunctions characterized by autoimmune responses to the enzyme class of transglutaminases. The present invention provides a novel open structure of the transglutaminases in a stabilized form which renders new epitopes accessible for antibody-binding.

Stabilized open form transglutaminase as a diagnostic indictor for autoimmune diseases

Growing community of inventors

Darmstadt, Germany

Martin Hils