Fresenius Hemocare Gmbh

Fresenius Medical Care Deutschland Gmbh

Martin Hepper

Hans-Peter Leinenbach

Veit Otto

Wolfgang Metzger

Frank Nocken

Hans Peter Leinenbach

Heike Mitschulat

The present invention relates to an ex vivo method for increasing the effectiveness of antibodies and Fc&#x3b3; receptor-binding active ingredients, comprising the steps of: a) preparing a blood sample of a patient; b) subjecting the blood sample to an immunoapheresis; c) administering a therapeutically effective antibody or an Fc&#x3b3; receptor-binding active ingredient to the patient.

Methods for increasing the effectiveness of antibodies and/or FCY receptor-binding active ingredients

A process for manufacturing an adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma in which a carrier material, which is preferably a copolymer derived from (meth)acrylates and or (meth)acrylic acid amides, is activated by amination, and subsequently undergoes thermal treatment at a temperature of over 100&deg; C. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.

Process for manufacturing an adsorbent for reducing the concentration of fibrinogen and/or fibrin, an adsorbent and method of producing an adsorber from the adsorbent

An adsorbent for reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma comprises a matrix and synthetic lateral chains that are covalently bonded to the matrix. The lateral synthetic chains are comprised of at least two amino groups in which the N atoms are at least 2.6 &angst; apart within at least one lateral synthetic chain. The matrix exhibits porous, unaggregated, spherical particles in a range of particle sizes from 50 to 250 &mgr;m, which possess an exclusionary threshold of at least 10 Daltons, and they exhibit no peptides or aromatic groups of any kind. The at least two amino groups are preferably separated from one another by 4 to 6 carbon atoms. An adsorber for the purpose of reducing the concentration of fibrinogen and/or fibrin in blood or blood plasma may be produced from the adsorbent.

Adsorbent for reducing the concentration of fibrinogen and/or fibrin, method of producing an adsorber from the adsorbent, and an adsorber with the adsorbent

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Neustadt, Germany

Martin Hepper