The United States Government As Represented by the Department of Veterans Affairs

University of Arkansas

Universidad Tecnica Particular De Loja

Bioventures, LLC

Tocol Pharmaceuticals, LLC

Martin Hauer-Jensen

Cesar M Compadre

Philip J Breen

Nukhet Aykin-Burns

Darin E Jones

Shraddha Thakkar

Omar Malagon

Edgar Ojeda

E Nathalie Pineda

Raul G Enriquez

Sujay Kharade

Yadira Ordonez

Cesar Compadre

Philip Breen

Peter Anthony Crooks

Guangrong Zheng

Paivi Aho

Darin Jones

Peter Crooks

Omar Malagon AVILÉS

Nathalie E Pineda

Provided herein is a tocol rich fraction of rice bran oil deodorized distillate that is shown to be both radioprotective and able to protect against oxidative damage. This fraction may prove an inexpensive and readily available extract that can be used to prepare pharmaceutical compositions for use in protecting against radiation exposure and/or other forms of oxidative stress.

Use of rice bran oil distillate extract for prevention and mitigation of the effects of radiation

Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise &#x3b3;-tocotrienol (GT3) and &#x3b4;-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.

Preparation and use of a composition for prevention and mitigation of the effects of radiation

Methods for the synthesis of tocoflexols of Formula (I) and (II) and a number of related tocol analogs are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material.

Methods for making tocoflexols and analogues thereof

Intestinal radiation injury (radiation enteropathy) is an important dose limiting factor during treatment of abdominal and pelvic tumors and a major determinant in the quality of life among cancer survivors. Inflammatory and fibrogenic mediators released by mucosal inflammatory cells are involved in the mechanisms of injury. Treatment with Orazipone decreases the toxicity following Gy radiation dose, as measured by histopathologic scoring, TGF-&bgr;, IL-1&agr;, and ED- macrophage antigen immunoreactivity.

Method for reducing radiation toxicity

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Little Rock, AR, United States of America

Martin Hauer-Jensen